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Current Problems in Surgery
Volume 44, Issue 3
, Pages 157-216
, March 2007
Venous Thromboembolism and Cancer
References
- . Making health care safer: a critical analysis of patient safety practices. Evid Rep Technol Assess (Summ). 2001;43:1–668i-x
- Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126:338-400S
- . Prevention of fatal postoperative pulmonary embolism by low doses of heparin (An international multicentre trial). Lancet. 1975;2:45–51
- . Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin (Overview of results of randomized trials in general, orthopedic, and urologic surgery). N Engl J Med. 1988;318:1162–1173
- . IMPROVE, a multinational observational cohort study of practices in prevention of venous thromboembolism in acutely ill medical patients: a comparison with clinical study populations. Blood. 2003;102:3l9a. 5
- . Thrombosis risk factor assessment in surgical patients: compliance with chest consensus guidelines. J Thromb Haemost. 2003;1(Suppl 1):CD125
- . Compliance with ACCP Guidelines for Prevention of Venous Thromboembolism: Multinational findings from the global orthopaedic registry (GLORY). Blood. 2003;102:165a
- Utilization of venous thromboprophylaxis in acutely ill medical patients in Canada: results from the Canadian Registry (CURVE). Blood. 2003;102:498a
- Prevention of venous thromboembolism: adherence to the 1995 American College of Chest Physicians consensus guidelines for surgical patients. Arch Intern Med. 2000;160:334–340
- . Missed opportunities for prevention of venous thromboembolism: an evaluation of the use of thromboprophylaxis guidelines. Chest. 2001;120:1964–1971
- . Practices in the prevention of venous thromboembolism. J Thromb Thrombolysis. 1998;5:S7–S11
- . Underuse of venous thromboembolism prophylaxis for general surgery patients: physician practices in the community hospital setting. Arch Intern Med. 1998;158:1909–1912
- . Postoperative pulmonary embolism after hospital discharge: an underestimated risk. Arch Surg. 1992;127:310–313
- . Duration of venous thromboembolism prophylaxis after surgery. Chest. 2003;124(6 Suppl):386S–392S
- . Incidence of posthospitalization proximal deep venous thrombosis after total hip arthroplasty (A pilot study). Clin Orthop. 1994;299:203–208
- . Incidence of venous thromboembolism verified by necropsy over 30 years. BMJ. 1991;302:709–711
- . Risk factors for major thromboembolism and bleeding tendency after elective general surgical operations. Eur J Surg. 1996;162:783–789
- Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. Lancet. 1993;341:259–265
- . Low molecular weight heparin and unfractionated heparin in thrombosis prophylaxis after major surgical intervention: update of previous meta-analyses. Br J Surg. 1997;84:750–759
- . Prevention of venous thromboembolism in general surgical patients (Results of a meta-analysis). Ann Surg. 1988;208:227–240
- Low molecular weight heparin versus standard heparin in general and orthopedic surgery: a metaanalysis. Lancet. 1992;340:152–156
- . Prophylaxis of postoperative thromboembolism with low molecular weight heparins. Br J Surg. 1993;80:689–704
- . Estimated annual number of incident and recurrent, non-fatal and fatal venous thromboembolism (VTE) events in the US. [abstract] Blood. 2005;106:910
- . Diagnosis of deep vein thrombosis: review of clinical evaluation and impedance plethysmography. Am J Surg. 1985;150:7–13
- . Effective risk stratification of surgical and nonsurgical patients for venous thromboembolic disease. Semin Hematol. 2001;38(2 Suppl 5):12–19
- . Postoperative venous thrombosis (Evaluation of five methods of treatment). Am J Surg. 1981;141:245–251
- Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX study. Arch Intern Med. 2004;164:963–968
- . Incidence of venous thromboembolism: a community-based study in Western France. Thromb Haemost. 2000;83:657–660
- . Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000;160:809–815
- Risk factors for venous thromboembolic events in cancer patients. Ann Oncol. 2006;17:297–303
- A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. N Engl J Med. 1999;341:793–800
- . Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients. Circulation. 2004;110:874–879
- Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ. 2006;332:325–329
- . Pneumatic sequential compression reduces the risk of deep vein thrombosis in stroke patients. Neurology. 1998;50:1683–1688
- . Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology. 2005;65:865–869
- Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med. 2005;352:969–977
- . Fact Sheet. AHRQ Publication No. 04-P025. Rockville, MD: AHRQ; 2005;March. http://www.ahrq.gov (accessed 28 February 2006).
- . Cancer and thrombosis. Haemostasis. 1994;24:128–131
- . The hypercoagulable state of malignancy: pathogenesis and current debate. Neoplasia. 2002;4:465–473
- . Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000;160:809–815
- . Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158:585–593
- . Venous thromboembolism and cancer: risks and outcomes. Circulation. 2003;107(23 Suppl 1):I17–I21
- . Cancer Facts & Figures. 2006;Available at http://www.cancer.org/docroot/stt/stt_0.asp. accessed 16 August 2006.
- Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med. 2002;162:1245–1248
- . Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA. 2005;293:715–722
- . Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med. 2006;119:60–68
- Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy (Risk analysis using Medicare claims data). Medicine (Baltimore). 1999;78:285–291
- . Venous thrombosis in patients with solid tumors: determination of frequency and characteristics. Thromb Haemost. 2002;87:575–579
- . Variation in relative risk of venous thromboembolism in different cancers. Thromb Haemost. 2002;87:1076–1077
- . Thromboembolism complicating surgery for cervical and uterine malignancy: incidence, risk factors, and prophylaxis. Obstet Gynecol. 1983;61:87–94
- . Epidemiology of thrombosis in cancer. Acta Haematol. 2001;106:6–12
- The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996;125:1–7
- Deep-vein thrombosis and the incidence of subsequent symptomatic cancer. N Engl J Med. 1992;327:1128–1133
- . Undiagnosed malignancy in patients with deep vein thrombosis: incidence, risk indicators, and diagnosis. Cancer. 1998;83:180–185
- . Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer. Cancer. 1986;57:1846–1849
- . Occult cancer in patients with venous thromboembolism: which patients, which cancers. Thromb Haemost. 1997;78:1316–1318
- . Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism (Duration of Anticoagulation Trial). N Engl J Med. 2000;342:1953–1958
- . The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med. 1998;338:1169–1173
- The clinical course of pulmonary embolism. N Engl J Med. 1992;326:1240–1245
- The outcome after treatment of venous thromboembolism is different in surgical and acutely ill medical patients (Findings from the RIETE registry). J Thromb Haemost. 2004;2:1892–1898
- . Prognosis of cancers associated with venous thromboembolism. N Engl J Med. 2000;343:1846–1850
- . Fatal pulmonary embolism in cancer patients: is heparin prophylaxis justified?. South Med J. 1980;73:841–843
- . An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med. 2000;160:3415–3420
- . Venous thromboembolism associated with long-term use of central venous catheters in cancer patients. J Clin Oncol. 2003;21:3665–3675
- . Prevention and treatment of venous thromboembolism (International Consensus Statement(guidelines according to scientific evidence)). Int Angiol. 2006;25:101–161
- . Primary thromboprophylaxis for cancer patients with central venous catheters—a reappraisal of the evidence. Br J Cancer. 2006;94:189–194
- . Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study. Cancer. 2005;104(12):2822–2829
- . Lenalidomide and venous thrombosis in multiple myeloma. N Engl J Med. 2006;354:2079–2080
- . Prevention of post-operative deep leg vein thrombosis in patients with cancer. Thromb Haemost. 1997;78:126–132
- . NCCN Clinical Practice Guidelines in Oncology (Venous Thromboembolic Disease, version 1). 2006;http://www.nccn.org/professionals/physician_gls/PDF/vte.pdf. Accessed 2006.
- . Venous thrombosis in cancer patients: insights from the FRONTLINE survey. Oncologist. 2003;8:381–388
- . Thromboprophylaxis in the cancer patient. Acta Haematol. 2001;106:73–80
- Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med. 2002;346:975–980
- Double-blind randomised trial of a very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer. Lancet. 1994;343:886–889
- Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349:146–153
- Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and thromboembolism. J Clin Oncol. 2005;23:2123–2129
- . Anticoagulants in thrombosis and cancer: the missing link. Semin Thromb Hemost. 2002;28:45–52
- . Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci USA. 2001;98:3352–3357
- Subcutaneous heparin treatment increases survival in small cell lung cancer. Cancer. 1994;74:38–45
- The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol. 2005;23:2130–2135
- A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer. J Thromb Haemost. 2004;2:1266–1271
- Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate (Final report of VA Cooperative Study #75). Cancer. 1984;53:2046–2052
- . Phlegmasia alba dolens (Clinique Medicale de l‘Hotel-Dieu de Paris). 2nd edition. Paris: Bailliere; 1865;
- Resistance to activated protein C, factor V Leiden and the prothrombin G20210A variant in patients with colorectal cancer. Pathophysiol Haemost Thromb. 2002;32:2–7
- A clinical outcome-based prospective study on venous thromboembolism after cancer surgery: the RISTOS project. Ann Surg. 2006;243:89–95
- . Deep venous thrombosis and occult malignancy: an epidemiological study. BMJ. 1994;308:891–894
- . Venous thromboembolism and cancer. Lancet. 1998;351:1077–1080
- . Trousseau’s syndrome—what is the evidence? (A population-based autopsy study). Thromb Haemost. 2006;95:541–545
- . Hypercoagulability preceding cancer (Venous thromboembolism and subsequent cancer risk). J Thromb Haemost. 2005;3:583–584
- . Evaluation of perioperative fatal pulmonary embolism and death in cancer surgical patients: the MC-4 cancer substudy. Thromb Haemost. 2005;94:867–871
- . Meta-analysis of low molecular weight heparin in the prevention of venous thromboembolism in general surgery. Br J Surg. 2001;88:913–930
- . Postoperative deep venous thrombosis and infectious complications (A clinical study of patients undergoing colo-rectal surgery). Scand J Infect Dis. 1980;12:123–127
- . Prophylaxis of deep venous thrombosis in colorectal surgery. Dis Colon Rectum. 1982;25:563–566
- . Deep vein thrombosis complicating colorectal surgery in the Chinese in Singapore. Ann Acad Med Singapore. 1993;22:895–897
- Wille-Jorgensen P, Rasmussen MS, Andersen BR, Borly L. Heparins and mechanical methods for thromboprophylaxis in colorectal surgery. Cochrane Database Syst Rev 2003(4):CD001217.
- . Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep vein thrombosis in elective cancer surgery: a double-blind randomized multicentre trial with venographic assessment. Br J Surg. 1997;84:1099–1103
- Low molecular weight heparin started before surgery as prophylaxis against deep vein thrombosis: 2500 versus 5000 XaI units in 2070 patients. [see comments] Br J Surg. 1995;82:496–501
- . Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):188S–203S
- Regional anesthesia in the anticoagulated patient: defining the risks (the second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation). Reg Anesth Pain Med. 2003;28:172–197
- . Anticoagulation and neuraxial regional anesthesia: perspectives. Reg Anesth Pain Med. 2003;28:163–166
- Extended out-of-hospital low-molecular-weight heparin prophylaxis against deep venous thrombosis in patients after elective hip arthroplasty: a systematic review. Ann Intern Med. 2001;135:858–869
- . Deep venous thrombosis: a continuing problem. BMJ. 1988;297:28
- . Does prolonged thromboprophylaxis improve outcome in patients undergoing surgery?. Cancer Treat Rev. 2003;29(Suppl 2):15–17
- . Effect of anticoagulant drugs in cancer. Curr Opin Pulm Med. 2005;11:403–407
- . Do heparins do more than just treat thrombosis? (The influence of heparins on cancer spread). Thromb Haemost. 1999;82:947–952
- Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol. 2004;22:1944–1948
- . New ways to prevent venous thromboembolism—the pentasaccharide fondaparinux and the thrombin inhibitor ximelagatran—a review. Acta Chir Belg. 2005;105:35–39
- . Prolonged prophylaxis against venous thromboembolism with enoxaparin inpatients undergoing cancer surgery (Long-term survival analysis). Phlebology. 2006;(In press)
- . Heparin and cancer. Thromb Haemost. 1998;80:10–23
- . Cancer and venous thromboembolism. Lancet Oncol. 2005;6:401–410
- . Hypercoagulability preceding cancer (Are anticoagulants also antineoplastic?). J Thromb Haemost. 2005;3:581–583
- . Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies. Arch Intern Med. 2002;162:1833–1840
- . Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Br J Surg. 2005;92:1212–1220
- Pharmacokinetics, preliminary efficacy and safety of subcutaneous melagatran and oral ximelagatran, A multicentre study on thromboprophylaxis in elective abdominal surgery. Clin Drug Invest. 2004;24:127–136
- Hepatic findings in long-term clinical trials of ximelagatran. Drug Saf. 2005;28:351–370
- Anonymous Is that it, then, for blockbuster drugs?. Lancet. 2004;9440:1100;Sept. 25-Oct 1
- . Deep vein thrombosis of the leg (Is there a “high risk” group?). Am J Surg. 1970;120:527–530
- . A study of pulmonary embolism and deep leg vein thrombosis after major gynaecological surgery using labelled fibrinogen-phlebography and lung scanning. J Obstet Gynaecol Br Commonw. 1974;81:311–316
- . Prophylaxis of postoperative leg vein thrombosis by low dose subcutaneous heparin or peroperative calf muscle stimulation: a controlled clinical trial. BMJ. 1975;1:649–651
- . The use of graduated compression stockings in the prevention of postoperative deep vein thrombosis. Br J Surg. 1983;70:172–174
- . Pre-operative identification of patients at high risk of deep venous thrombosis after elective major abdominal surgery. Lancet. 1986;1:1173–1176
- Low dose heparin versus low molecular weight heparin (Kabi 2165, Fragmin) in the prophylaxis of thromboembolic complications of abdominal oncological surgery. Eur J Clin Invest. 1988;18:561–567
- . Randomized, controlled trial of low molecular weight heparin vs. no deep vein thrombosis prophylaxis for major colon and rectal surgery in Asian patients. Dis Colon Rectum. 1999;42:196–202discussion 202-3
- . Comparison of enoxaparin and standard heparin in gynaecologic oncologic surgery: a randomised prospective double-blind clinical study. Eur J Gynaecol Oncol. 2001;22:127–130
- Haemostatic molecular markers in patients undergoing radical retropubic prostatectomy for prostate cancer and submitted to prophylaxis with unfractioned or low molecular weight heparin. Minerva Anestesiol. 2001;67:693–703
- Subcutaneous heparin versus low-molecular-weight heparin as thromboprophylaxis in patients undergoing colorectal surgery: results of the Canadian Colorectal DVT Prophylaxis Trial: a randomized, double-blind trial. Ann Surg. 2001;233:438–444
- . Prophylaxis for venous thromboembolism during treatment for cancer: questionnaire survey. BMJ. 2003;327:597–598
- . Managing thromboembolic disease in the cancer patient: efficacy and safety of antithrombotic treatment options in patients with cancer. Cancer Treat Rev. 2002;28:145–149
- . Warfarin versus low-molecular-weight heparin therapy in cancer patients. Oncologist. 2005;10:72–79
- Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood. 2002;100:3484–3488
- . Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved International Normalized ratio: a retrospective analysis. J Clin Oncol. 2000;18:3078–3083
- . Treatment of venous thromboembolism in cancer patients. Cancer Control. 2005;12:17–21
- . Deep vein thrombosis in cancer: the scale of the problem and approaches to management. Ann Oncol. 2005;16:696–701
- . Management of thrombosis in cancer: primary prevention and secondary prophylaxis. Br J Haematol. 2004;128:291–302
- . Antithrombotic therapy for venous thromboembolic disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):401S–428S
- . Antithrombotic therapy with low molecular weight heparin in cancer patients. Eur J Med Res. 2004;9:119–124
- . A meta-analysis comparing low-molecular-weight heparins with unfractionated heparin in the treatment of venous thromboembolism: examining some unanswered questions regarding location of treatment, product type, and dosing frequency. Arch Intern Med. 2000;160:181–188
- . Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis (A meta-analysis of randomized, controlled trials). Ann Intern Med. 1999;130:800–809
- Selecting patients for home treatment of deep vein thrombosis: the problem of cancer. Haematologica. 2002;87:286–291
- . UK patients with deep-vein thrombosis can be safely treated as out-patients. QJM. 2000;93:663–667
- Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injection. Arch Intern Med. 1998;158:1809–1812
- Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. N Engl J Med. 1996;334:682–687
- A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med. 1996;334:677–681
- . Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. N Engl J Med. 1997;337:657–662
- . Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism. Cochrane Database Syst Rev. 2004;4:CD001100
- Subcutaneous enoxaparin once or twice daily compared with intravenous unfractionated heparin for treatment of venous thromboembolic disease. Ann Intern Med. 2001;134:191–202
- . Clivarin: Assessment of Regression of Thrombosis, Efficacy, and Safety (Effects of a low-molecular-weight heparin on thrombus regression and recurrent thromboembolism in patients with deep-vein thrombosis). N Engl J Med. 2001;344:626–631
- A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med. 1998;338:409–414
- . Prophylactic indications for vena cava filters: critical appraisal. Semin Vasc Surg. 2005;18:158–165
- . Secondary prevention of venous thromboembolic events (VTE) in patents with active malignancy: a randomized study of enoxaparin sodium alone vs. initial enoxaparin sodium followed by warfarin for a 180-day period. [abstract] J Thromb Haemost. 2003;1(Suppl 1):OC194
- . A randomized trial evaluating long-term low-molecular-weight heparin therapy for three months versus intravenous heparin followed by warfarin sodium. [abstract] J Thromb Haemost. 2003;1(Suppl 1):1373a
- Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med. 2002;162:1729–1735
- . Acceptability of low molecular weight heparin thromboprophylaxis for inpatients receiving palliative care: qualitative study. BMJ. 2006;332:577–580
- . Trousseau’s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine. 1977;56:1–37
- . Intravascular coagulation in cancer. Semin Oncol. 1978;5:203–211
- . Bleeding and intravascular clotting in malignancy: a review. Ann NY Acad Sci. 1974;230:271–288
- . Pathophysiology of the thrombophilic state in the cancer patient. Semin Thromb Hemost. 1999;25:173–182
- . Pathogenesis of thrombosis in patients with malignancy. Int J Hematol. 2001;73:137–144
- . Venous thromboembolism and occult malignancy. Thromb Res. 2001;102:V187–V194
- . Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis, and treatment. Am J Hematol. 2003;72:43–52
- . Molecular basis for the relationship between thrombosis and cancer. Thromb Res. 2001;V215–V224
- . The thrombophilic state induced by therapeutic agents in the cancer patient. Semin Thromb Hemost. 1999;25:137–145
- . Epidemiology and management of venous thromboembolism in patients with cancer. Thromb Res. 2003;110:167–172
- . The thrombogenic effect of cancer drug chemotherapy in women with stage II breast cancer. N Engl J Med. 1988;318:404–407
- . Venous and arterial thrombosis in patients who receive adjuvant therapy for breast cancer. J Clin Oncol. 1991;9:286–294
- Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with breast cancer. J Clin Oncol. 1996;14:2731–2737
- . Occult cancer in patients with bilateral deep-vein thrombosis. Lancet. 1997;350:1448–1449
- . Factors associated with recurrent venous thromboembolism in patients with malignant disease. J Vasc Surg. 2003;37:976–983
- . Antithrombotic strategies in patients with cancer. Thromb Hemost. 1997;78:141–144
- . A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol. 2004;93:259–262
- . Thrombotic complications of central venous catheters in cancer patients. Semin Thromb Hemost. 1999;25:147–155
- . Risk factors associated with venous thromboembolic events in patients with malignancy. Blood Coag Fibrinol. 2006;17:265–270
- . Thromboembolism is hospitalized neutropenic cancer patients. J Clin Oncol. 2006;24:484–490
- . Human tumor procoagulants: registry of the Subcommittee on Haemostasis and Malignancy of the Scientific and Standardization Committee, International Society on Thrombosis and Haemostasis. Thromb Haemost. 1993;69:205–213
- Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am J Pathol. 1998;152:399–411
- . Clotting mechanisms and cancer: implications in thrombus formation and tumor progression. Clin Adv Hematol Oncol. 2003;11:673–678
- . The prothrombotic state in cancer: pathogenic mechanisms. Clin Rev Oncol Hematol. 2004;50:187–196
- . Inflammation and cancer. Nature. 2002;420:860–867
- . Interaction of vascular endothelial cells with leukocytes, platelets and cancer cells in inflammation, thrombosis and cancer growth and metastasis. Acta Pharmacol Sin. 2003;24:1297–1300
- . Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell. 1991;65:859–873
- . Platelet-derived MP express high affinity receptors for factor VIII. J Biol Chem. 1991;266:17261–17268
- . Endothelial cell activation by leukocyte microparticles. J Immunol. 1998;161:4382–4387
- . Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity. Blood. 2002;99:3962–3970
- . Microparticles in cardiovascular diseases. Cardiovasc Res. 2003;59:277–287
- Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003;197:1585–1598
- . Shed membrane microparticles from circulating and vascular cells in regulating vascular function. Am J Physiol Heart Circ Physiol. 2005;288:H1004–H1009
- . The nature and significance of platelet products in human plasma. Br J Haematol. 1967;13:269–288
- . Cellular microparticles: a disseminated storage pool of bioactive vascular effectors. Curr Opin Hematol. 2004;11:156–164
- . Cell-derived microparticles: “Miniature envoys with many faces.”. J Thromb Haemost. 2005;3:884–887
- The association between tissue-factor exposing microparticles and the activation of the coagulation system in cancer patients. Blood. 2004;104:2589
- . Extremely high levels of microvesicle-associated tissue factor in patients with cancer-related thrombosis. Blood. 2004;104:2605
- Endothelial derived microparticles (EMP) bind and complex with unusually-large multimers of von Willebrand factor (ULvWF) and act as potent inducers of platelet adhesion and aggregation. Blood. 2004;104:3376
- . Membrane microparticles: two sides of the coin. Physiology (Bethesda). 2005;20:22–27
- Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men. Am J Cardiol. 2005;95:1258–1260
- Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism. J Am Coll Cardiol. 2005;45:1467–1471
- . Detached endothelial cells and microparticles as sources of tissue factor activity. Thromb Res. 2005;116:409–419
- . Cancer-associated thrombosis. Blood Cells Mol Dis. 2006;36:177–181
- . Tumor shedding and coagulation. Science. 1981;212:923–924
- Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells. Cancer Res. 1983;43:4434–4442
- . Tumor generation of thrombin via functional prothrombinase assembly. Cancer Res. 1985;45:5521–5525
- Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood. 2004;105:1734–1741
- . Trousseau’s syndrome revisited (Tissue factor-bearing microparticles in pancreatic cancer). Blood. 2005;106:259A
- . P-selectin and leukocyte microparticles are associated with venous thrombogenesis. J Vasc Surg. 2003;38:1075–1089
- D-Dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis (A pilot study). Thromb Haemost. 2005;94:1312–1317
- . Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell. 1989;56:1033–1044
- . Platelet-endothelial interactions in inflamed mesenteric venules. Blood. 1998;91:1318–1324
- Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med. 1992;175:1147–1150
- Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors. J Cell Biol. 1998;142:1381–1391
- . The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J. 2003;24:2166–2179
- . P-Selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis. Arch Immunol Ther Exp (Warsz). 2006;54:75–84
- . Soluble bio-markers in vascular disease: much more than gauges of disease?. Clin Exp Pharmacol Physiol. 2005;32:233–240
- . Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest. 1997;100:2085–2093
- P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med. 2000;191:1413–1422
- Re-expression of functional P-selectin molecules on the endothelial cell surface by repeated stimulation with thrombin. Br J Haematol. 1997;97:348–355
- Chronic expression of P-selectin on endothelial cells stimulated by the T-cell cytokine, interleukin-3. Blood. 1996;87:1432–1438
- . Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-alpha in vivo. Cell Adhes Commun. 1994;2:7–14
- . Cloning of the mouse endothelial selectins (Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha). J Biol Chem. 1992;267:15176–15183
- Production of soluble P-selectin by platelets and endothelial cells. Biochemistry (Moscow). 1999;64:1326–1335
- . Comparison of GP IIB/IIIA inhibitors and their activity as measured by aggregometry, flow cytometry, single platelet counting, and the rapid platelet function analyzer. J Thromb Thrombolysis. 2001;12:129–139
- . Regulation of P-selectin expression in human endothelial cells by nitric oxide. Am J Physiol. 1997;273:H740–H746
- . Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide. J Cardiol. 1999;33:103–104
- . P-Selectin glycoprotein ligand 1 is a ligand for L-selectin on neutrophils, monocytes, and CD34+ hematopoietic progenitor cells. J Cell Biol. 1996;135:523–531
- . Functional and structural characterization of the eosinophil P-selectin ligand. J Immunol. 1996;157:1711–1719
- Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med. 2003;9:1020–1025
- P-Selectin and TNF inhibition reduce venous thrombosis inflammation. J Surg Res. 1996;64:26–31
- Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature. 1992;359:848–851
- Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res. 2002;108:212–221
- Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res. 2003;109:1–7
- Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis. J Vasc Surg. 1997;25:816–827
- Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy. J Vasc Surg. 2000;31:309–324
- Treatment with an oral small molecule inhibitor of P-selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006;44:625–632
- . Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand-1. Blood. 1995;86:4417–4421
- . Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci USA. 1995;92:7450–7454
- . Pro-coagulant state resulting from high levels of soluble P-selectin in blood. Proc Natl Acad Sci USA. 2000;97:13835–13840
- . The presence and release of tissue factor from human platelets. Platelets. 2002;13:247–253
- Blood-borne tissue factor; another view of thrombosis. Proc Natl Acad Sci USA. 1999;96:2311–2315
- . Platelet factor 3 in plasma fractions: its relation to microparticle size and thromboses. Thromb Res. 1995;80:471–482
- The ability of different forms of heparin to suppress P-selectin function in vitro correlates to their inhibitory capacity on blood-borne metastasis in vivo. Thromb Haemost. 2006;95:535–540
- . P-Selectin and leukocyte microparticles are associated with venous thrombogenesis. J Vasc Surg. 2003;38:1075–1089
- Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003;197:1585–1598
- . Mononuclear cell tissue factor: cell of origin and requirements for activation. Blood. 1979;54:359–370
- . Abnormalities of blood coagulation in people with cancer (Mononuclear cell tissue factor generation). J Lab Clin Med. 1981;98:917–928
- . Tissue factor and angiogenesis in cancer. Curr Opin Hematol. 2002;9:401–406
- . Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA. 1995;92:8205–8209
- . Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. J Clin Invest. 1998;101:1372–1378
- . Thrombin signaling and protease-activated receptors. Nature. 2000;407:258–264
- . Specificity of coagulation factor signaling. J Thromb Hemost. 2003;1:1495–1503
- . A role of tissue factor in cell adhesion and migration mediated by interaction with actin binding protein. J Cell Biol. 1998;140:1241–1253
- Localization of tissue factor in actin filament-rich membrane areas of epithelial cells. Exp Cell Res. 1999;248:136–147
- . Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc Natl Acad Sci USA. 1992;89:11832–11836
- Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor. J Clin Invest. 1999;104:1213–1221
- . Does hypercoagulability awaken dormant tumor cells in the host?. J Thromb Hemost. 2004;2:2103–2106
- . Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res. 2001;61:5933–5940
- . Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol. 2005;25:1545–1550
- . The hemostatic system as a regulator of angiogenesis. J Biol Chem. 2000;275:1521–1524
- Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest. 1994;94:1320–1327
- Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. Proc Natl Acad Sci USA. 1999;96:8663–8668
- . Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor. Lancet. 1995;346:1004–1005
- Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J. 2003;17:476–478
- . Tissue factor on the loose. Semin Thromb Hemost. 2000;26:379–384
- . The P-selectin, tissue factor coagulation triad. J Thromb Hemost. 2005;3:1590–1596
- Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. Eur J Cancer. 2003;39:184–191
- . Biological and clinical aspects of anticancer effects of antithrombotics. Pathophys Haemost Thromb. 2003;33:389–392
- . Prevention and treatment of deep vein thrombosis in cancer patients. Vessels. 1996;2:31–34
- . Low molecular weight heparins and unfractionated heparin in the treatment of patients with acute venous thromboembolism: results of a meta-analysis. Am J Med. 1996;100:269–277
- . Cancer and thromboembolic disease: pathogenic mechanisms. Cancer Treatment Rev. 2002;28:137–140
PII: S0011-3840(07)00015-9
doi: 10.1067/j.cpsurg.2007.01.004
© 2007 Mosby, Inc. All rights reserved.
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Current Problems in Surgery
Volume 44, Issue 3
, Pages 157-216
, March 2007
