Current Problems in Surgery
Volume 45, Issue 7 , Pages 453-516 , July 2008

Advances in Surgical Critical Care

  • George C. Velmahos, MD, PhD, MSEd

      Affiliations

    • John F. Burke Professor of Surgery, Harvard Medical School, Chief, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Hasan B. Alam, MD

      Affiliations

    • Associate Professor of Surgery, Harvard Medical School, Director of Research, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts

References 

  1. Joint Commission on Accreditation of Healthcare Organizations (JCAHO). The specifications manual for national hospital quality measures—ICU (2005). http://www.jointcommission.org/PerformanceMeasurement/MeasureReserveLibrary/Spec+Manual+-+ICU.htmAccessed November 16, 2007.
  2. Pronovost PJ, Needham DM, Waters H, et al. Intensive care unit staffing: financial modeling of the Leapfrog standard. Crit Care Med. 2004;32:1247–1253
  3. Halpern NA, Pastores SM, Greenstein RG. Critical care medicine in the United States 1985–2000: an analysis of bed numbers, use and costs. Crit Care Med. 2004;32:1254–1259
  4. Wadell G. Movement of critically ill patients within hospital. BMJ. 1975;2:417–419
  5. Insel J, Weissman C, Kemper M, et al. Cardiovascular changes during transport of critically ill and postoperative patients. Crit Care Med. 1986;14:539–542
  6. Smith I, Fleming S, Cernaianu A. Mishaps during transport from the intensive care unit. Crit Care Med. 1990;18:278–281
  7. Indeck M, Peterson S, Smith J, Brotman S. Risk, cost, and benefit of transporting ICU patients for special studies. J Trauma. 1988;28:1020–1025
  8. Warren J, Fromm RE, Orr RA, et al. Guidelines for the inter- and intrahospital transport of critically ill patients. Crit Care Med. 2004;32:256–262
  9. Van Natta TL, Morris JA, Eddy VA, et al. Elective bedside surgery in critically injured patients is safe and cost-effective. Ann Surg. 1998;227:618–626
  10. Tola JC, Holtzman R, Lottenberg L. Bedside placement of inferior vena cava filters in the intensive care unit. Am Surg. 1999;65:833–837
  11. Nunn CR, Neuzil D, Naslund T, et al. Cost-effective method for bedside insertion of vena caval filters in trauma patients. J Trauma. 1997;43:752–756
  12. Lujan HJ, Dries DJ, Gamelli RL. Comparative analysis of bedside and operating room tracheostomies in critically ill patients with burns. J Burn Care Rehabil. 1995;16:258–261
  13. Barba CA, Angood PB, Kauder DR, et al. Bronchoscopic guidance makes percutaneous tracheostomy a safe, cost-effective, and easy-to-teach procedure. Surgery. 1995;118:879–883
  14. Ciaglia P, Firsching R, Syniec C. Elective percutaneous dilational tracheostomy (A new simple bedside procedure: preliminary report). Chest. 1985;87:715
  15. Dulguerov P, Gysin C, Perneger TV, Chevrolet JC. Percutaneous or surgical tracheostomy: a meta-analysis. Crit Care Med. 1999;27:1617–1625
  16. Velmahos GC. Bedside tracheostomy. In:  Shoemaker WC,  Velmahos GC,  Demetriades D editor. Procedures and Monitoring for the Critically Ill. Philadelphia: WB Saunders Company; 2002;p. 31–42
  17. Velmahos GC, Gomez H, Boicey CM, Demetriades D. Bedside percutaneous tracheostomy: prospective evaluation of a modification of the current technique in 100 patients. World J Surg. 2000;24:1109–1115
  18. Porter JM, Ivatury RR. Preferred route of tracheostomy—percutaneous versus open at the bedside: a randomized, prospective study in the surgical intensive care unit. Am Surg. 1999;65:142–146
  19. Hazard P, Jones C, Benitone J. Comparative trial of standard operative tracheostomy with percutaneous technique. Crit Care Med. 1991;19:1018–1024
  20. Crofts SL, Alzeer A, McGuire GP, Wong DT, Charles D. A comparison of percutaneous and operative tracheostomies in intensive care patients. Can J Anaesth. 1995;42:775–779
  21. Friedman Y, Fildes J, Mizock B, et al. Comparison of percutaneous and surgical tracheostomies. Chest. 1996;110:480–485
  22. Gysin C, Dulguerov P, Guyot JP, Perneger T, Blanca A, Chevrolet JC. Percutaneous versus surgical tracheostomy: a double-blind randomized trial. Ann Surg. 1999;230:708–713
  23. Heikkinen M, Aarnio P, Hannukainen J. Percutaneous dilational tracheostomy or conventional surgical tracheostomy?. Crit Care Med. 2000;28:1399–1401
  24. Massick DD, Shonan Y, Powell DM, et al. Bedside tracheostomy in the intensive care unit: a prospective randomized trial comparing open surgical tracheostomy with endoscopically guided percutaneous dilational tracheostomy. Laryngoscope. 2001;111:494–500
  25. Gauderer MW, Ponsky JL, Izant RJ. Gastrostomy without laparotomy: a percutaneous endoscopic technique. J Pediatr Surg. 1980;15:872–875
  26. Hogan RB, DeMarco DC, Hamilton JK, Walker CO, Polter DE. Percutaneous endoscopic gastrostomy: to push or pull. A prospective randomized trial. Gastrointest Endosc. 1986;32:253
  27. Sharma VK, Howden CW. Meta-analysis of randomized, controlled trials of antibiotic prophylaxis before percutaneous endoscopic gastrostomy. Am J Gastroenterol. 2001;96:1951–1952
  28. Karmy-Jones R, Jurkovich G, Velmahos GC, et al. Practice patterns and outcomes after retrievable vena cava filters in trauma patients: a AAST multicenter study. J Trauma. 2007;62:17–25
  29. Sing RF, Cicci CK, Smith CH, Messick WJ. Bedside insertion of inferior vena cava filters in the intensive care unit. J Trauma. 1999;47:1104–1107
  30. Sato DT, Robinson KD, Gregory RT, Gayle RG, Parent FN, DeMasi RJ, et al. Duplex directed caval filter insertion in multi-trauma and critically ill patients. Ann Vasc Surg. 1999;13:365–371
  31. Garrett JV, Passman MA, Guzman RJ, Dattilo JB, Naslund TC. Expanding options for bedside placement of inferior vena cava filters with intravascular ultrasound when transabdominal duplex ultrasound imaging is inadequate. Ann Vasc Surg. 2004;18:329–334
  32. Connors AF, Speroff T, Dawson NV, et al. The effectiveness of right heart catheterization in the initial care of critically ill patients. JAMA. 1996;276:889–897
  33. Summers RL, Shoemaker WC, Peacock F, Ander DS, Coleman TG. Bench to bedside: electrophysiologic and clinical principles of noninvasive hemodynamic monitoring using impedance cardiography. Acad Emerg Med. 2003;10:669–680
  34. Raajmakers E, Faes THJ, Scholten J, Goovaerts G, Heetaar RM. A meta-analysis of three decades of validating thoracic impedance cardiography. Crit Care Med. 1999;27:1203–1213
  35. Velmahos GC, Wo CC, Demetriades D, et al. Invasive and non-invasive physiological monitoring of blunt trauma patients in the early period after emergency admission. Int Surg. 1999;84:354–360
  36. Shoemaker WC, Belzberg H, Wo CCJ, et al. Multicenter study of noninvasive monitoring as alternatives to invasive monitoring of acutely ill emergency patients. Chest. 1998;114:1643–1652
  37. Norris PR, Ozdas A, Cao H, et al. Cardiac uncoupling and heart rate variability stratify patients by mortality (A study of 2088 trauma patients). Ann Surg. 2006;243:804–814
  38. Papaioannou VE, Maglaveras N, Houvard I, Antoniadou E, Vretzakis G. Investigation of altered heart rate variability, nonlinear properties of heart rate signals, and organ dysfunction longitudinally over time in intensive care unit patients. J Crit Care. 2006;21:95–103
  39. Convertino VA, Cooke WH, Holcomb JB. Arterial pulse pressure and its association with reduced stroke volume during progressive central hypovolemia. J Trauma. 2006;61:629–634
  40. Tremper KK, Waxman K, Bowman R, et al. Continuous transcutaneous oxygen monitoring during respiratory failure, cardiac decompensation, cardiac arrest, and CPR. Crit Care Med. 1980;8:377–381
  41. Tatevossian RG, Wo CC, Velmahos GC, Demetriades D, Shoemaker WC. Transcutaneous oxygen and CO2 as early warning of tissue hypoxia and hemodynamic shock in critically ill emergency patients. Crit Care Med. 2000;28:2248–2253
  42. Creteur J. Gastric and sublingual capnometry. Curr Opin Crit Care. 2006;12:272–277
  43. Gutierrez G, Palizas F, Doglio G, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet. 1992;339:195–199
  44. Miami Trauma Clinical Trials Group. Splanchnic hypoperfusion-directed therapies in trauma: a prospective randomized trial. Am Surg. 2005;71:252–260
  45. Weil MH, Nakagawa Y, Tang W, et al. Sublingual capnometry: a new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med. 1999;27:1225–1229
  46. Cohn SM, Crookes BA, Proctor KG. Near-infrared spectroscopy in resuscitation. J Trauma. 2003;54:S199–S202
  47. Rhee P, Langdale L, Mock C, Gentilello LM. Near-infrared spectroscopy: continuous measurement of cytochrome oxidation during hemorrhagic shock. Crit Care Med. 1997;25:166–170
  48. Cohn SM, Nathens AB, Moore FA, Rhee P, Puyana JC, Moore EE, et al. StO2 in Trauma Patients Trial Investigators (Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation). J Trauma. 2007;62:44–54
  49. Cholley BP, Payen D. Noninvasive techniques for measurement of cardiac output. Curr Opin Crit Care. 2005;11:424–429
  50. Goedje O, Hoeke K, Lichtwarck-Aschoff M, et al. Continuous cardiac output by femoral arterial thermodilution calibrated pulse contour analysis: comparison with pulmonary arterial thermodilution. Crit Care Med. 1999;27:2407–2412
  51. Hofer CK, Furrer L, Matter-Esner S, et al. Volumetric preload measurement by thermodilution: a comparison with transesophageal echocardiograph. Br J Anaesth. 2005;94:748–755
  52. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38:185–193
  53. Dutton RP, Mackenzie CF, Scalea TM. Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality. J Trauma. 2002;52:1141–1146
  54. Rotondo MF, Schwab CW, McGonigal MD, Phillips GR, Fruchterman TM, Kauder DR, et al. “Damage control”: an approach for improved survival in exsanguinating penetrating abdominal trauma. J Trauma. 1993;35:375–383
  55. Mapstone J, Roberts I, Evans P. Fluid resuscitation strategies: a systematic review of animal trials. J Trauma. 2003;55:571–589
  56. Liberman M, Mulder D, Sampalis J. Advanced or basic life support for trauma: meta-analysis and critical review of the literature. J Trauma. 2000;49:584–599
  57. Bickel WH, Wall MJ, Pepe PE, Martin RR, Ginger VF, Allen MK, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105–1109
  58. Kwan I, Bunn F, Roberts I. WHO Pre-Hospital Trauma Care Steering Committee (Timing and volume of fluid administration for patients with bleeding following trauma). Cochrane Database Syst Rev. 2003;3:CD002245
  59. Pope A, French G, Longnecker DE. State of the science for testing combat casualties and civilian injuries (Institute of Medicine). Washington, DC: National Academy Press; 1999;
  60. Alam HB. An update on fluid resuscitation. Scand J Surg. 2006;95:136–145
  61. Klein MB, Hayden D, Elson C, et al. The association between fluid administration and outcome following major burn (A multicenter study). Ann Surg. 2007;245:622–628
  62. Gwande A. Casualties of war—military care for the wounded from Iraq and Afghanistan. N Engl J Med. 2004;351:2471–2475
  63. Bunn F, Roberts I, Tasker R. Hypertonic versus near isotonic crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2004;3:CD002045
  64. Wade CE, Kramer GC, Grady JJ, Fabian TC, Younes RN. Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies. Surgery. 1997;122:609–616
  65. Bulger EM, Cuschieri J, Warner K, Maier RV. Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock. Ann Surg. 2007;245:635–641
  66. Resuscitation Outcomes Consortium. https://roc.uwctc.org/tiki/tiki-index.phpAccessed November 19, 2007.
  67. The SAFE Study Investigators. Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med. 2007;357:874–884
  68. Gonzales EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients receiving massive transfusion. J Trauma. 2007;62:112–119
  69. Rivers E, Nguyen B, Havstad S, et al. Early Goal-Directed Therapy Collaborative Group Early goal directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368–1377
  70. Mullner M, Urbanek B, Havel C, et al. Vasopressors for shock. Cochrane Database Syst Rev. 2004;3:CD003709
  71. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion in critical care. N Engl J Med. 1999;340:409–417
  72. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2007;Dec 4 (Epub ahead of print)
  73. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353:1685–1693
  74. Rammath VR, Hess DR, Thompson BT. Conventional mechanical ventilation in acute lung injury and acute respiratory distress syndrome. Clin Chest Med. 2006;27:601–613
  75. Slutsky AS. Mechanical ventilation: American College of Chest Physicians' Consensus Conference. Chest. 1993;104:1833–1859[Erratum, Chest 1994;106:656].
  76. Amato MBP, Barbas CSV, Medeiros DM, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998;338–354
  77. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301-8.
  78. Petrucci N, Iacovelli W. Lung protective ventilation strategy for the acute respiratory distress syndrome. Cochrane Database Syst Rev. 2007;3:CD003844
  79. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351:327–336
  80. Villar J, Kacmarek RM, Pérez-Méndez L, Aguirre-Jaime A ARIES Network. A high PEEP-low tidal volume ventilatory strategy improves outcome in persistent ARDS (A randomized controlled trial). Crit Care Med. 2006;34:1311–1318
  81. National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564–2575
  82. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet. 1999;354:1851–1858
  83. Gattinoni L, Tognoni G, Pesenti A, Taccone P, et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med. 2001;345:568–573
  84. Guerin C, Gaillard S, Lemasson S, Ayzac L, et al. Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA. 2004;292:2379–2387
  85. Mancebo J, Fernández R, Blanch L, Rialp G, et al. A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006;173:1233–1239
  86. Meduri GU, Headley AS, Golden E, et al. Effect of prolonged methylprednisolone therapy in unresolving in acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1998;280:159–165
  87. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med. 2006;354:1671–1684
  88. Adhikari N, Burns KEA, Meade MO. Pharmacologic therapies for adults with acute lung injury and acute respiratory distress syndrome. Cochrane Database Syst Rev. 2004;4:CD004477
  89. Sokol Jacobs SE, Bohn D. Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults. Cochrane Database Syst Rev. 2003;1:CD002787
  90. Griffiths MJD, Evans TW. Inhaled nitric oxide therapy in adults. N Engl J Med. 2005;353:2683–2695
  91. Fan E, Stewart TE. New modalities of mechanical ventilation: high frequency oscillatory ventilation and a airway pressure release ventilation. Clin Chest Med. 2006;27:615–625
  92. Gorecki PJ, Schein M, Mehta V, Wise L. Surgeons and infectious disease specialists: different attitudes towards antibiotic treatment and prophylaxis in common abdominal surgical infections. Surg Inf. 2000;1:115–123
  93. Malacarne P, Rossi C, Bertolini G GiViTI Group. Antibiotic usage in intensive care units: a pharmaco-epidemiological multicentre study. J Antimicrob Chemother. 2004;54:221–224
  94. Liberati A, D'Amico R, Pifferi S, Telaro E. Antibiotic prophylaxis in intensive care units: meta-analyses versus clinical practice. Intensive Care Med. 2000;26:S38–S44(suppl 1).
  95. Mannien J, van Kasteren ME, Nagelkerke NJ, et al. Effect of optimized antibiotic prophylaxis on the incidence of surgical site infection. Infect Control Hosp Epidemiol. 2006;27:1340–1346
  96. Tan JA, Naik VN, Lingard L. Exploring obstacles to proper timing of prophylactic antibiotics for surgical site infections. Qual Safety Health Care. 2006;15:32–38
  97. Cornwell EE, Dougherty WR, Berne TV, et al. Duration of antibiotic prophylaxis in high-risk patients with penetrating abdominal trauma: a prospective randomized trial. J Gastrointest Surg. 1999;3:648–653
  98. Velmahos GC, Jindal A, Chan L, et al. Prophylactic antibiotics after severe trauma: more is not better. Int Surg. 2001;86:176–183
  99. Namias N, Harvill S, Ball S, McKenney MG, Salomone JP, Civetta JM. Cost and morbidity associated with antibiotic prophylaxis in the ICU. J Am Coll Surg. 1999;188:225–230
  100. Silvestri L, van Saene HK, Milanese M, Gregori D, Gullo A. Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients (Systematic review of randomized, controlled trials). J Hosp Infect. 2007;65:187–203
  101. Stoutenbeek CP, van Saene HK, Little RA, Whitehead A Working Group on Selective Decontamination of the Digestive Tract. The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial. Intensive Care Med. 2007;33:261–270
  102. Alvarez-Lerma F. Modification of empiric treatment in patients with pneumonia acquired in the intensive care unit: ICU-Acquired Pneumonia Study Group. Intensive Care Med. 1996;22:387–394
  103. Kollef MH, Ward S, Sherman G, et al. Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices. Crit Care Med. 2000;28:3456–3464
  104. Iregui M, Ward S, Sherman G, et al. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest. 2002;122:262–268
  105. Raymond DP, Pelletier SJ, Crabtree TD, et al. Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Crit Care Med. 2001;29:1101–1108
  106. Kollef MH, Vlasnik J, Sharpless L, Pasque C, Murphy D, Fraser V. Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med. 1997;156:1040–1048
  107. Warren DK, Hill HA, Merz LR, et al. Cycling empirical antibiotic agents to prevent emergence of antimicrobial-resistant Gram-negative bacteria among intensive care unit patients. Crit Care Med. 2004;32:2450–2456
  108. Van Loon HJ, Vriens MR, Fluit AC. Antibiotic rotation and development of gram-negative antibiotic resistance. Am J Respir Crit Care Med. 2005;171:480–487
  109. Bernard GR, Vincent J-L, Laterre P-F, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699–709
  110. Barie PS, Hydo LJ, Shou J, Eachempati SR. Efficacy and safety of drotrecogin alfa (activated) for the therapy of surgical patients with severe sepsis. Surgical Infect. 2006;7(suppl 2):S77–S80
  111. Polk JC, Lewis JN, Garrison NR, Van Vlack JP, Houck PM, Hunt DR. Process and outcome measures in specialty surgery: early steps in defining quality. Bull Am Coll Surg. 2005;90(2):8–13
  112. NIH Consensus Development Conference on Total Knee Replacement, National Institutes of Health, Bethesda, MD, December 8-10, 2003.
  113. AHRQ Evidence Report/Technology Assessment, Number 22. Prevention of Venous Thromboembolism After Injury. AHRQ Publication No. 01-E004, Rockville, MD: AHRQ, November 2000.
  114. Kakkar VV, Corrigan T, Spindler J, et al. Efficacy of low doses of heparin in prevention of deep-vein thrombosis after major surgery (A double-blind, randomised trial). Lancet. 1972;2:101–106
  115. Kakkar VV, Corrigan TP, Fossard DP, et al. Prevention of fatal postoperative pulmonary embolism by low doses of heparin (An international multicentre trial). Lancet. 1975;2(7924):45–51
  116. Owings JT, Bagley M, Gosselin R, Romac D, Disbrow E. Effect of critical injury on plasma antithrombin activity: low antithrombin levels are associated with thromboembolic complications. J Trauma. 1996;41:396–406
  117. Greenfield LJ, Proctor MC, Rodriguez JL, Luchette FA, Cipolle MD, Cho J. Posttrauma thromboembolism prophylaxis. J Trauma. 1997;42:100–103
  118. Meissner MH, Chandler WL, Elliott JS. Venous thromboembolism in trauma: a local manifestation of systemic hypercoagulability?. J Trauma. 2003;54:224–231
  119. Cook D, Crowther M, Meade M, et al. Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors. Crit Care Med. 2005;33:1565–1571
  120. Velmahos GC, Nigro J, Tatevossian R, et al. Inability of an aggressive policy of thromboprophylaxis to prevent deep venous thrombosis (DVT) in critically injured patients: are current methods of DVT prophylaxis insufficient?. J Am Coll Surg. 1998;187:529–533
  121. Cornwell EE, Chang D, Velmahos GC, et al. Compliance with sequential compression device prophylaxis in at-risk trauma patients: a prospective analysis. Am Surg. 2002;68:470–473
  122. Jacobs DG, Piotrowski JJ, Hoppensteadt DA, et al. Hemodynamic and fibrinolytic consequences of intermittent pneumatic compression: preliminary results. J Trauma. 1996;40:710–716
  123. Limpus A, Chaboyer W, McDonald E, Thalib L. Mechanical thromboprophylaxis in critically ill patients: a systematic review and meta-analysis. Am J Crit Care. 2006;15:402–410
  124. Rocha AT, Tapson VF. Venous thromboembolism in intensive care patients. Clin Chest Med. 2003;24:103–122
  125. Cook DJ, Rocker G, Meade M PROTECT Investigators. Canadian Critical Care Trials Group (Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study). J Crit Care. 2005;20:364–372
  126. Geerts WH, Jay RM, Code KI, et al. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med. 1996;335:701–707
  127. Knudson MM, Morabito D, Paiement GD, Schackleford S. Use of low molecular weight heparin in preventing thromboembolism in trauma patients. J Trauma. 1996;41:446–459
  128. Ginzburg E, Cohn SM, Lopez K, et al. Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in trauma. Br J Surg. 2003;90:1338–1344
  129. Merli G Spinal Cord Injury Thromboprophylaxis Investigators. Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: a randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin. J Trauma. 2003;54:1116–1126
  130. Palmer AJ, Koppenhagen K, Kirchhof B, Weber U, Bergemann R. Efficacy and safety of low molecular weight heparin, unfractionated heparin, and warfarin for thrombo-embolism prophylaxis in orthopaedic surgery: a meta-analysis of randomised clinical trials. Haemostasis. 1997;27:75–84
  131. Rutherford EJ, Schooler WG, Sredszienski E, Abrams JE, Skeete DA. Optimal dose of enoxaparin in critically ill trauma and surgical patients. J Trauma. 2005;58:1167–1170
  132. Priglinger U, Deel Karth G, Geppert A, et al. Prophylactic anticoagulation with enoxaparin: is the subcutaneous route appropriate in the critically ill?. Crit Care Med. 2003;31:1405–1409
  133. Turpie AG, Bauer KA, Erikson BI, Lassen MR. Superiority of fondaparinux over enoxaparin in preventing venous thromboembolism in major orthopedic surgery using different efficacy and points. Chest. 2004;126:501–508
  134. Singelyn FJ, Verheyen CC, Piovella F, et al. The safety and efficacy of extended thromboprophylaxis with fondaparinux after major orthopedic surgery of the lower limb with or without a neuraxial or deep peripheral nerve catheter: the EXPERT study. Anesth Analg. 2007;105:1540–1547
  135. Kuo KH, Kovacs MJ. Fondaparinux: a potential new therapy for HIT. Hematology. 2005;10:271–275
  136. Bauer KA. New anticoagulants. Hematology. 2006;405–406
  137. Spyropoulos AC. Investigational treatments of venous thromboembolism. Expert Opin Investig Drugs. 2007;16:431–440
  138. McMurty AL, Owings JT, Anderson JT, Battistella FD, Gosselin R. Increased use of prophylactic vena cava filters in trauma patients failed to decrease overall incidence of pulmonary embolism. J Am Coll Surg. 1999;189:314–320
  139. Decousous H, Leizorvicz A, Parent F, et al. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med. 1998;338:409–415
  140. Yun AJ, Lee PY, Bazar KA. Can thromboembolism be the result, rather than the inciting cause, of acute vascular events such a stroke, pulmonary embolism, mesenteric ischemia, and venous thrombosis? (A maladaptation of the prehistoric trauma response). Med Hypotheses. 2005;64:706–716
  141. Martin MJ, Salim A. Vena cava filters in surgery and trauma. Surg Clin N Am. 2007;87:1229–1252
  142. Velmahos GC, Kern J, Chan LS, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report—part I: analysis of risk factors and evaluation of the role of vena caval filters. J Trauma. 2000;49:132–138
  143. Agnelli G, Bergqvist D, Cohen AT, et al. Randomized clinical trial of postoperative fondaparinux versus postoperative dalteparin for the prevention of venous thromboembolism in high-risk abdominal surgery. Br J Surg 205;92:1212-20.
  144. Enoxacan Study Group. Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep venous thrombosis in elective cancer surgery: a double blind randomized multicentre trial with venographic assessment. Br J Surg. 1997;84:1099–1113
  145. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism (The seventh ACCP conference on antithrombotic and thrombolytic therapy). Chest. 2004;126:338S–400S
  146. Moore FA, Feliciano DV, Andrassy RJ, et al. Early enteral feeding compared to parenteral, reduces postoperative complications (The results of a meta-analysis). Ann Surg. 1992;216:172–183
  147. Koretz RL, Lipman TO, Klein S. AGA technical review on parenteral nutrition. Gastroenterology. 2001;121:970–1001
  148. Braunschweig CL, Levy P, Sheean PM, Wang X. Enteral compared with parenteral nutrition: a meta-analysis. Am J Clin Nutr. 2001;74:534–542
  149. Gramlich L, Kichian K, Pinilla J, Rodych NJ, Dhaliwal R, Heyland DK. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? (A systematic review of the literature). Nutrition. 2004;20:843–848
  150. Peter JV, Moran JL, Phillips-Hughes J. A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients. Crit Care Med. 2005;33:213–220
  151. Simpson F, Doig GS. Parenteral vs enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Med. 2005;31:12–23
  152. Rhee P, Hadjizacharia P, Trankiem , et al. What happened to total parenteral nutrition? (The disappearance of its use in a trauma intensive care unit). J Trauma. 2007;63:1215–1222
  153. Koretz RL, Avenell A, Lipman TO, Braunschweig CL, Milne AC. Does enteral nutrition affect clinical outcome? (A systematic review of the randomized trials). Am J Gastroenterol. 2007;102:412–429
  154. Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery: a systematic review and meta-analysis of randomized trials in the English language. J Gastrointest Surg. 2007;Oct 16 (Epub ahead of print)
  155. Lewis SJ, Egger M, Sylvester PA, Thomas S. Early enteral feeding versus “nil by mouth” after gastrointestinal surgery: systematic review and meta-analysis of controlled trials. BMJ. 2001;323:1–5
  156. Weeks EC. Controversies in the determination of energy requirements. Proc Nutr Soc. 2007;66:367–377
  157. Ochoa JB, Caba D. Advances in surgical nutrition. Surg Clin North Am. 2006;86:1483–1493
  158. Jeejeebhoy KN. Permissive underfeeding of the critically ill patient. Nutr Clin Pract. 2004;19:477–480
  159. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN J Parenter Enteral Nutr. 2002;26(1 suppl):1SA–138SA
  160. Cerra FB, Benitez MR, Blackburn GL, et al. Applied nutrition in ICU patients (A consensus statement of the American College of Chest Physicians). Chest. 1997;111:769–778
  161. Stapleton RD, Jones N, Heyland DK. Feeding critically ill patients: what is the optimal amount of energy?. Crit Care Med. 2007;35:S535–S540
  162. Klein CJ, Stanek L, Wiles CE. Overfeeding macronutrients to critically ill adults: metabolic complications. J Am Diet Assoc. 1998;98:795–806
  163. Brandi LS, Santini L, Bertolini R, et al. Energy expenditure and severity of injury and illness indices in multiple trauma patients. Crit Care Med. 1999;27:2684–2689
  164. Heyland DK, Dhaliwal R, Drover JW, et al. Canadian clinical practice guidelines for nutritional support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr. 2003;27:355–373
  165. Heyland DK, Dhaliwal R, Day A, et al. Validation of the Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients: results of a prospective observational study. Crit Care Med. 2004;32:2260–2266
  166. Marik PE, Zaloga GP. Early enteral nutrition in acutely ill patients: a systematic review. Crit Care Med. 2001;29:2264–2270
  167. Bauer P, Charpentier C, Bouchet C, et al. Parenteral with enteral nutrition in the critically ill. Intensive Care Med. 2000;26:893–900
  168. Dhaliwal R, Jurewitsch B, Harrietha D, Heyland DK. Combination enteral and parenteral nutrition in critically ill patients; harmful or beneficial? (A systematic review of the evidence). Intensive Care Med. 2004;30:1666–1671
  169. MacFie J, Woodcock NP, Palmer MD, et al. Oral dietary supplements in pre- and postoperative surgical patients: a prospective and randomized clinical trial. Nutrition. 2000;16:723–728
  170. Dechelotte P, Hasselmann M, Cynober L, et al. L-Alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study. Crit Care Med. 2006;34:598–604
  171. Novak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med. 2002;30:2022–2029
  172. Consensus recommendations from the US summit on immune-enhancing enteral therapy. JPEN J Parenter Enteral Nutr. 2001;25:S61–S63
  173. Heys SD, Walker LG, Smith I, Eremin O. Enteral nutritional supplementation with key nutrients in patients with patients with critical illness and cancer. Ann Surg. 1999;229:467–477
  174. Braga M, Gianotti L, Nespoli L, Radaelli G, Di Carlo V. Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg. 2002;137:174–180
  175. Bertolini G, Iapichino G, Radrizzani D, et al. Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med. 2003;29:834–840
  176. Gadek JE, DeMichele SJ, Karlstad MD, et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and anti-oxidants in patients with acute respiratory distress syndrome (Enteral nutrition in ARDS study group). Crit Care Med. 1999;27:1409–1420
  177. Singer P, Theilla M, Fisher H, et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med. 2006;34:1033–1038
  178. Pontes-Arruda A, Araqao AM, Albuquerque JD. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med. 2006;34:2325–2333
  179. Garrel D, Patenaude J, Nedelec B, et al. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial. Crit Care Med. 2003;31:2444–2449
  180. Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? (A systematic review of the evidence). JAMA. 2001;286:944–953
  181. Montejo JC, Zarazago A, Lopez-Martinez J. Immunonutrition in the intensive care unit (A systematic review and consensus statement). Clin Nutr. 2003;22:2221–2233
  182. Kieft H, Roos AN, van Drunen JDE, et al. Clinical outcome of immunonutrition in a heterogeneous intensive care population. Intensive Care Med. 2005;31:524–532
  183. Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in critically ill patients. J Trauma. 2003;55:33–38
  184. Ellger B, Debaveye Y, Vanhorebeek I, et al. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent action of insulin. Diabetes. 2006;55:1096–1105
  185. Van den Berghe G, Wouters PJ, Bouillion R, et al. Outcome benefit of intensive insulin therapy in critically ill: insulin dose versus glycemic control. Crit Care Med. 2003;31:359–366
  186. Van den Berghe G, Wilmer A, Milants I, et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefits versus harm. Diabetes. 2006;55:3151–3159
  187. Lacherade JC, Jabre P, Bastuji-Garin S, et al. Failure to achieve glycemic control despite intensive insulin therapy in a medical ICU: incidence and influence on ICU mortality. Intensive Care Med. 2007;33:814–821
  188. Quattara A, Lecomte P, Le Manach Y, et al. Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients. Anesthesiology. 2005;103:687–694
  189. Gandhi GY, Nuttall GA, Abel MD, et al. Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc. 2005;80:862–866
  190. Gandhi GY, Nuttall GA, Abel MD, et al. Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery. Ann Intern Med. 2007;146:233–243
  191. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;325:1359–1367
  192. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449–461
  193. Malhotra A. Intensive insulin in intensive care. N Engl J Med. 2006;354:516–518
  194. Van den Berghe G, Wouters PJ, Kesteloot K, Hilleman DE. Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients. Crit Care Med. 2006;34:612–616
  195. Krinsley JS, Jones RL. Cost analysis of intensive glycemic control in critically ill adult patients. Chest. 2006;129:644–650
  196. Egi M, Bellomo R, Stachowski E, et al. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006;105:244–252
  197. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295:1681–1687
  198. Malmberg K, Ryden L, Wedel H, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGMI 2): effects on mortality and morbidity. Eur Heart J. 2005;26:650–661
  199. The CREATE-ECLA Trial Group Investigators. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA. 2005;293:437–446
  200. Brunkhorst FM, Kuhnt E, Engel C, et al. Intensive insulin therapy in patients with severe sepsis and septic shock is associated with an increased rate of hypoglycemia—results from a randomized multicenter study (VISEP). [abstract] Infection. 2005;33(suppl 1):19
  201. Glucontrol study. comparing the effects of two glucose control regimens by insulin in intensive care unit patients. http://clinicaltrials.gov/ct2/show/NCT00107601Accessed December 20, 2007.
  202. Vriesendorp TM, DeVries JH, Van Santen S, et al. Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med. 2006;34:2714–2718
  203. Krinsly JS, Grover A. Severe hypoglycemia in critically ill patients; risk factors and outcomes. Crit Care Med. 2007;35:2261–2267
  204. Wilson M, Weinreb J, Soo Hoo GW. Intensive insulin therapy in critical care: a review of 12 protocols. Diabetes Care. 2007;30:1005–1011
  205. Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE–SUGAR STUDY). Accessed December 20, 2007. http://clinicaltrials.gov/ct2/show/NCT00220987
  206. Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288:861–871
  207. Annane D, Maxime V, Ibrahim F, et al. Diagnosis of adrenal insufficiency in severe sepsis and septic shock. Am J Resp Crit Care Med. 2006;174:1319–1326
  208. Briegel J, Forst H, Haller M, Schelling G, et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med. 1999;27:723–732
  209. Bollaert PE, Charpentier C, Levy B, Debouverie M, et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med. 1998;26:645–650
  210. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111–124
  211. Briegel J, Vogeser M, Annane D, Keh D, et al. Measurement of cortisol in septic shock: interlaboratory harmonization. [abstract] Am Rev Resp Crit Care Med. 2007;175:A436
  212. Lipiner-Friedman D, Sprug CL, Laterre PF, et al. Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med. 2007;35:1012–1018
  213. Briegel J, Kilger E, Schelling G. Indications and practical use of replacement dose of corticosteroids in critical illness. Curr Opin Crit Care. 2007;13:370–375
  214. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296–327Erratum in Crit Care Med 2008;36:1394-6
  215. Rie MA. Kofke WA (Nontherapeutic quality improvement: the conflict of organizational ethics and societal rule of law). Crit Care Med. 2007;35(2 suppl):S66–S84
  216. American College of Chest Physicians/Society for Critical Care Medicine Consensus Panel. Ethical and moral guidelines for initiation, continuation, and withdrawal of intensive care. Chest. 1990;7:949–952
  217. Sullivan DJ, Hansen-Flaschen J. Termination of life support after major trauma. Surg Clin North Am. 2000;80:1055–1066
  218. Prendergast TJ, Luce JM. Increasing incidence of withholding and withdrawal of life support from the critically ill. Am J Resp Care Med. 1997;155:15–21
  219. Guidelines for the determination of death (Report of the medical consultants on the diagnosis of death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research). JAMA. 1981;246:2184–2186
  220. Reis CE MedStudents. http://www.medstudents.com.br/neuro/neuro5.htmAccessed December 20, 2007
  221. Salim A, Brown C, Inaba K, et al. Improving consent rates for organ donation: the effect of an inhouse coordinator program. J Trauma. 2007;62:1411–1414
  222. Truog RD, Robinson WM. Role of brain death and the dead-donor rule in the ethics of organ transplantation. Crit Care Med. 2003;31:2391–2396

PII: S0011-3840(08)00054-3

doi: 10.1067/j.cpsurg.2008.03.003

Current Problems in Surgery
Volume 45, Issue 7 , Pages 453-516 , July 2008

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