Current Problems in Surgery
Volume 45, Issue 9 , Pages 587-661 , September 2008

Current Status of Hepatic Transplantation

  • Dieter C. Broering, MD, PhD

      Affiliations

    • Head Professor of Transplant Surgery/Surgical Oncology, University Hospital of Schleswig-Holstein Campus, Kiel, Germany
  • ,
  • Jessica Walter, MD

      Affiliations

    • Assistant Attending, Department of Surgery, University Hospital of Schleswig-Holstein Campus, Kiel, Germany
  • ,
  • Felix Braun, MD

      Affiliations

    • Head of the Transplant Outpatient Clinic, University Hospital of Schleswig-Holstein Campus, Kiel, Germany
  • ,
  • Xavier Rogiers, MD, PhD

      Affiliations

    • Head Professor of Transplant Surgery, University of Ghent, Ghent, Belgium

References 

  1. Couinaud C. Le foie. Etudes anatomique et chirurgicales. Paris: Masson; 1957;
  2. Henderson JM, Heymsfield SB, Horowitz J, Kutner MH. Measurement of liver and spleen volume by computed tomography (Assessment of reproducibility and changes found following a selective distal splenorenal shunt). Radiology. 1981;141:525–527
  3. Couinaud C. Surgical Anatomy of the Liver Revisited. Paris: Couinaud; 1989;
  4. Imamura H, Makuuchi M, Sakamoto Y, Sugawara Y, Sano K, Nakayama A, et al. Anatomical keys and pitfalls in living donor liver transplantation. J Hepatobiliary Pancreat Surg. 2000;7:380–394
  5. Couinaud C. Liver anatomy: portal (and suprahepatic) or biliary segmentation. Dig Surg. 1999;16:459–467
  6. Hiatt JR, Gabbay J, Busuttil RW. Surgical anatomy of the hepatic arteries in 1000 cases. Ann Surg. 1994;220:50–52
  7. Kawarada Y, Das BC, Taoka H. Anatomy of the hepatic hilar area: the plate system. J Hepatobiliary Pancreat Surg. 2000;7:580–586
  8. Reichert PR, Renz JF, D'Albuquerque LA, Rosenthal P, Lim RC, Roberts JP, et al. Surgical anatomy of the left lateral segment as applied to living-donor and split-liver transplantation: a clinicopathologic study. Ann Surg. 2000;232:658–664
  9. Northover JM, Terblanche J. A new look at the arterial supply of the bile duct in man and its surgical implications. Br J Surg. 1979;66:379–384
  10. Stapleton GN, Hickman R, Terblanche J. Blood supply of the right and left hepatic ducts. Br J Surg. 1998;85:202–207
  11. Guiney MJ, Kruskal JB, Sosna J, Hanto DW, Goldberg SN, Raptopoulos V. Multi-detector row CT of relevant vascular anatomy of the surgical plane in split-liver transplantation. Radiology. 2003;229:401–407
  12. Makuuchi M, Hasegawa H, Yamazaki S, Bandai Y, Watanabe G, Ito T. The inferior right hepatic vein: ultrasonic demonstration. Radiology. 1983;148:213–217
  13. Renz JF, Kin C, Kinkhabwala M, Jan D, Varadarajan R, Goldstein M, et al. Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation. Ann Surg. 2005;242:556–563discussion 563-5
  14. Reich DJ, Munoz SJ, Rothstein KD, Nathan HM, Edwards JM, Hasz RD, et al. Controlled non-heart-beating donor liver transplantation: a successful single center experience, with topic update. Transplantation. 2000;70:1159–1166
  15. Busuttil RW, Tanaka K. The utility of marginal donors in liver transplantation. Liver Transpl. 2003;9:651–663
  16. Alexander JW, Vaughn WK. The use of “marginal” donors for organ transplantation (The influence of donor age on outcome). Transplantation. 1991;51:135–141
  17. Alexander JW, Vaughn WK, Carey MA. The use of marginal donors for organ transplantation: the older and younger donors. Transplant Proc. 1991;23:905–909
  18. De Carlis L, Colella G, Sansalone CV, Aseni P, Rondinara GF, Slim AO, et al. Marginal donors in liver transplantation: the role of donor age. Transplant Proc. 1999;31:397–400
  19. Gonzalez FX, Rimola A, Grande L, Antolin M, Garcia-Valdecasas JC, Fuster J, et al. Predictive factors of early postoperative graft function in human liver transplantation. Hepatology. 1994;20:565–573
  20. Feng S, Goodrich NP, Bragg-Gresham JL, Dykstra DM, Punch JD, DebRoy MA, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant. 2006;6:783–790
  21. Wilms C, Walter J, Kaptein M, Mueller L, Lenk C, Sterneck M, et al. Long-term outcome of split liver transplantation using right extended grafts in adulthood: a matched pair analysis. Ann Surg. 2006;244:865–872discussion 872-3
  22. Broering DC, Topp S, Schaefer U, Fischer L, Gundlach M, Sterneck M, et al. Split liver transplantation and risk to the adult recipient: analysis using matched pairs. J Am Coll Surg. 2002;195:648–657
  23. Ghobrial RM, Yersiz H, Farmer DG, Amersi F, Goss J, Chen P, et al. Predictors of survival after In vivo split liver transplantation: analysis of 110 consecutive patients. Ann Surg. 2000;232:312–323
  24. Emond JC, Freeman RB, Renz JF, Yersiz H, Rogiers X, Busuttil RW. Optimizing the use of donated cadaver livers: analysis and policy development to increase the application of split-liver transplantation. Liver Transpl. 2002;8:863–872
  25. Broering DC, Schulte am Esch J, Rogiers X. Consequences of anatomy for the split liver surgeon. In:  Rogiers X,  Bismuth H,  Busuttil RW,  Broering DC,  Azoulay D editor. Split Liver Transplantation. Darmstadt: Springer; 2002;p. 46–62
  26. Couinaud C, Houssin D. Analysis of the anatomical difficulties of bipartition. Paris: Couinaud; 1991;
  27. Broering DC, Wilms C, Lenk C, Schulte am Esch J, Schonherr S, Mueller L, et al. Technical refinements and results in full-right full-left splitting of the deceased donor liver. Ann Surg. 2005;242:802–812discussion 812-3
  28. Toso C, Ris F, Mentha G, Oberholzer J, Morel P, Majno P. Potential impact of in situ liver splitting on the number of available grafts. Transplantation. 2002;74:222–226
  29. Rogiers X, Bismuth H, Busuttil RW, Broering DC, Azoulay D. Split Liver Transplantation. Darmstadt: Springer; 2002;
  30. Schemmer P, Nickkholgh A, Hinz U, Gerling T, Mehrabi A, Sauer P, et al. Extended donor criteria have no negative impact on early outcome after liver transplantation: a single-center multivariate analysis. Transplant Proc. 2007;39:529–534
  31. Silberhumer GR, Pokorny H, Hetz H, Herkner H, Rasoul-Rockenschaub S, Soliman T, et al. Combination of extended donor criteria and changes in the model for end-stage liver disease score predict patient survival and primary dysfunction in liver transplantation: a retrospective analysis. Transplantation. 2007;83:588–592
  32. Maluf DG, Edwards EB, Kauffman HM. Utilization of extended donor criteria liver allograft: Is the elevated risk of failure independent of the model for end-stage liver disease score of the recipient?. Transplantation. 2006;82:1653–1657
  33. Cameron A, Busuttil RW. AASLD/ILTS transplant course: is there an extended donor suitable for everyone?. Liver Transpl. 2005;11:S2–S5
  34. Casavilla A, Ramirez C, Shapiro R, Nghiem D, Miracle K, Bronsther O, et al. Experience with liver and kidney allografts from non-heart-beating donors. Transplantation. 1995;59:197–203
  35. D'Alessandro AM, Hoffmann RM, Knechtle SJ, Odorico JS, Becker YT, Musat A, et al. Liver transplantation from controlled non-heart-beating donors. Surgery. 2000;128:579–588
  36. Otero A, Gomez-Gutierrez M, Suarez F, Arnal F, Fernandez-Garcia A, Aguirrezabalaga J, et al. Liver transplantation from Maastricht category 2 non-heart-beating donors. Transplantation. 2003;76:1068–1073
  37. Abt PL, Desai NM, Crawford MD, Forman LM, Markmann JW, Olthoff KM, et al. Survival following liver transplantation from non-heart-beating donors. Ann Surg. 2004;239:87–92
  38. Berlakovich GA. Wasting your organ with your lifestyle and receiving a new one?. Ann Transplant. 2005;10:38–43
  39. Watt KD, McCashland TM. Transplantation in the alcoholic patient. Semin Liver Dis. 2004;24:249–255
  40. Laederach-Hofmann K, Bunzel B. Noncompliance in organ transplant recipients: a literature review. Gen Hosp Psychiatry. 2000;22:412–424
  41. Bunzel B, Laederach-Hofmann K. Noncompliance in organ transplantation: a review. Wien Klin Wochenschr. 2000;112:423–440
  42. Berquist RK, Berquist WE, Esquivel CO, Cox KL, Wayman KI, Litt IF. Adolescent non-adherence: prevalence and consequences in liver transplant recipients. Pediatr Transplant. 2006;10:304–310
  43. Schaffellner S, Jakoby E, Kniepeiss D, Stadlbauer V, Duller D, Iberer F, et al. Center experience in liver transplantation (LTX): management of dermal side effects caused by sirolimus. Int Immunopharmacol. 2005;5:137–140
  44. Aalamian Z. Reducing adverse effects of immunosuppressive agents in kidney transplant recipients. Prog Transplant. 2001;11:271–282quiz 283-4
  45. Tricot L, Lebbe C, Pillebout E, Martinez F, Legendre C, Thervet E. Tacrolimus-induced alopecia in female kidney-pancreas transplant recipients. Transplantation. 2005;80:1546–1549
  46. Behrend M, Braun F. Enteric-coated mycophenolate sodium: tolerability profile compared with mycophenolate mofetil. Drugs. 2005;65:1037–1050
  47. Gane EJ, Portmann BC, Naoumov NV, Smith HM, Underhill JA, Donaldson PT, et al. Long-term outcome of hepatitis C infection after liver transplantation. N Engl J Med. 1996;334:815–820
  48. Alsatie M, Chalasani N, Kwo PY. Management of hepatitis C infection after liver transplantation. Drugs. 2007;67:871–885
  49. Berenguer M, Royuela A, Zamora J. Immunosuppression with calcineurin inhibitors with respect to the outcome of HCV recurrence after liver transplantation: results of a meta-analysis. Liver Transpl. 2007;13:21–29
  50. Roche B, Samuel D. Risk factors for hepatitis C recurrence after liver transplantation. J Viral Hepat. 2007;14(suppl 1):89–96
  51. Keck ZY, Machida K, Lai MM, Ball JK, Patel AH, Foung SK. Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies. Curr Top Microbiol Immunol. 2008;317:1–38
  52. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693–699
  53. Yao FY, Ferrell L, Bass NM, Watson JJ, Bacchetti P, Venook A, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology. 2001;33:1394–1403
  54. Yao FY, Ferrell L, Bass NM, Bacchetti P, Ascher NL, Roberts JP. Liver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria. Liver Transpl. 2002;8:765–774
  55. Toso C, Meeberg GA, Bigam DL, Oberholzer J, Shapiro AM, Gutfreund K, et al. De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects. Transplantation. 2007;83:1162–1168
  56. Schwartz M, Roayaie S, Uva P. Treatment of HCC in patients awaiting liver transplantation. Am J Transplant. 2007;7:1875–1881
  57. Freeman RB. Transplantation for hepatocellular carcinoma: the Milan criteria and beyond. Liver Transpl. 2006;12:S8–S13
  58. Marelli L, Stigliano R, Triantos C, Senzolo M, Cholongitas E, Davies N, et al. Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies. Cancer Treat Rev. 2006;32:594–606
  59. Vilca-Melendez H, Heaton ND. Paediatric liver transplantation: the surgical view. Postgrad Med J. 2004;80:571–576
  60. McDiarmid SV, Anand R, Lindblad AS. Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation. Transplantation. 2002;74:173–181
  61. Kiuchi T, Kasahara M, Uryuhara K, Inomata Y, Uemoto S, Asonuma K, et al. Impact of graft size mismatching on graft prognosis in liver transplantation from living donors. Transplantation. 1999;67:321–327
  62. Humar A, Ramcharan T, Sielaff TD, Kandaswamy R, Gruessner RW, Lake JR, et al. Split liver transplantation for two adult recipients: an initial experience. Am J Transplant. 2001;1:366–372
  63. Azoulay D, Castaing D, Adam R, Savier E, Delvart V, Karam V, et al. Split-liver transplantation for two adult recipients: feasibility and long-term outcomes. Ann Surg. 2001;233:565–574
  64. Renz JF, Emond JC, Yersiz H, Ascher NL, Busuttil RW. Split-liver transplantation in the United States: outcomes of a national survey. Ann Surg. 2004;239:172–181
  65. Merion RM, Rush SH, Dykstra DM, Goodrich N, Freeman RB, Wolfe RA. Predicted lifetimes for adult and pediatric split liver versus adult whole liver transplant recipients. Am J Transplant. 2004;4:1792–1797
  66. Dahm F, Georgiev P, Clavien PA. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant. 2005;5:2605–2610
  67. Clavien PA, Petrowsky H, DeOliveira ML, Graf R. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007;356:1545–1559
  68. Bolognesi M, Sacerdoti D, Bombonato G, Merkel C, Sartori G, Merenda R, et al. Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size. Hepatology. 2002;35:601–608
  69. Yersiz H, Renz JF, Farmer DG, Hisatake GM, McDiarmid SV, Busuttil RW. One hundred in situ split-liver transplantations: a single-center experience. Ann Surg. 2003;238:496–505discussion 506-7
  70. Whitington PF, Emond JC, Heffron T, Thistlethwaite JR. Orthotopic auxiliary liver transplantation for Crigler-Najjar syndrome type 1. Lancet. 1993;342:779–780
  71. Kasahara M, Kiuchi T, Uryuhara K, Ogura Y, Takakura K, Egawa H, et al. Treatment of ornithine transcarbamylase deficiency in girls by auxiliary liver transplantation: conceptual changes in a living-donor program. J Pediatr Surg. 1998;33:1753–1756
  72. Azoulay D, Samuel D, Ichai P, Castaing D, Saliba F, Adam R, et al. Auxiliary partial orthotopic versus standard orthotopic whole liver transplantation for acute liver failure: a reappraisal from a single center by a case-control study. Ann Surg. 2001;234:723–731
  73. Yersiz H, Renz JF, Hisatake G, Reichert PR, Feduska NJ, Lerner S, et al. Technical and logistical considerations of in situ split-liver transplantation for two adults: Part IICreation of left segment I-IV and right segment V-VIII grafts. Liver Transpl. 2002;8:78–81
  74. Yersiz H, Renz JF, Hisatake G, Reichert PR, Feduska NJ, Lerner S, et al. Technical and logistical considerations of in situ split-liver transplantation for two adults: Part I (Creation of left segment II, III, IV and right segment I, V-VIII grafts). Liver Transpl. 2001;7:1077–1080
  75. Sommacale D, Farges O, Ettorre GM, Lebigot P, Sauvanet A, Marty J, et al. In situ split liver transplantation for two adult recipients. Transplantation. 2000;69:1005–1007
  76. Humar A, Khwaja K, Sielaff TD, Lake JR, Payne WD. Technique of split-liver transplant for two adult recipients. Liver Transpl. 2002;8:725–729
  77. Feng L, Zhao N, Yao X, Sun X, Du L, Diao X, et al. Histidine-tryptophan-ketoglutarate solution vs (University of Wisconsin solution for liver transplantation: a systematic review). Liver Transpl. 2007;13:1125–1136
  78. Mangus RS, Tector AJ, Agarwal A, Vianna R, Murdock P, Fridell JA. Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution (UW) in adult liver transplantation. Liver Transpl. 2006;12:226–230
  79. Pokorny H, Rasoul-Rockenschaub S, Langer F, Windhager T, Rosenstingl A, Lange R, et al. Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation—a prospective multi-centre observation study. Transpl Int. 2004;17:256–260
  80. Lang H, Kamler M, Herold U, Malago M, Jakob H, Broelsch CE. Donor organ harvesting. Chirurg. 2002;73:517–535quiz 536-7
  81. Moench C, Moench K, Lohse AW, Thies J, Otto G. Prevention of ischemic-type biliary lesions by arterial back-table pressure perfusion. Liver Transpl. 2003;9:285–289
  82. Ben-Ari Z, Pappo O, Mor E. Intrahepatic cholestasis after liver transplantation. Liver Transpl. 2003;9:1005–1018
  83. Pichlmayr R, Ringe B, Gubernatis G, et al. Transplantation einer Spenderleber auf zwei Empfänger: (Spli liver transplantation) Eine neue Methode in der Weiterentwicklung der Lebersegmenttransplantation. Langenbecks Arch Chir. 1989;373:127–130
  84. Azoulay D, Astarcioglu I, Bismuth H, Castaing D, Majno P, Adam R, et al. Split-liver transplantation (The Paul Brousse policy). Ann Surg. 1996;224:737–746discussion 746-8
  85. Rogiers X, Malago M, Habib N, Knoefel WT, Pothmann W, Burdelski M, et al. In situ splitting of the liver in the heart-beating cadaveric organ donor for transplantation in two recipients. Transplantation. 1995;59:1081–1083
  86. Rogiers X, Malago M, Gawad K, Jauch KW, Olausson M, Knoefel WT, et al. In situ splitting of cadaveric livers (The ultimate expansion of a limited donor pool). Ann Surg. 1996;224:331–339discussion 339-341
  87. Colledan M, Andorno E, Valente U, Gridelli B. A new splitting technique for liver grafts. Lancet. 1999;353:1763
  88. Broering DC, Rogiers X, Malago M, Bassas A, Broelsch CE. Vessel loop-guided technique for parenchymal transection in living donor or in situ split-liver procurement. Liver Transpl Surg. 1998;4:241
  89. Starzl TE, Miller C, Broznick B, Makowka L. An improved technique for multiple organ harvesting. Surg Gynecol Obstet. 1987;165:343–348
  90. Lee S, Park K, Hwang S, Lee Y, Choi D, Kim K, et al. Congestion of right liver graft in living donor liver transplantation. Transplantation. 2001;71:812–814
  91. Gundlach M, Broering D, Topp S, Sterneck M, Rogiers X. Split-cava technique: liver splitting for two adult recipients. Liver Transpl. 2000;6:703–706
  92. Broering DC, Bok P, Mueller L, Wilms C, Rogiers X. Splitting of the middle hepatic vein in full-right full-left splitting of the liver. Liver Transpl. 2005;11:350–352
  93. Amador A, Charco R, Martí J, Navasa M, Rimola A, Calatayud D, et al. Clinical trial on the cost-effectiveness of T-tube use in an established deceased donor liver transplantation program. Clin Transpl. 2007;21:548–553
  94. Scatton O, Meunier B, Cherqui D, Boillot O, Sauvanet A, Boudjema K, et al. Randomized trial of choledochocholedochostomy with or without a T tube in orthotopic liver transplantation. Ann Surg. 2001;233:432–437
  95. Broering DC, Kim JS, Mueller T, Fischer L, Ganschow R, Bicak T, et al. One hundred thirty-two consecutive pediatric liver transplants without hospital mortality: lessons learned and outlook for the future. Ann Surg. 2004;240:1002–1012discussion 1012
  96. Stringer MD, Marshall MM, Muiesan P, Karani JB, Kane PA, Mieli-Vergani G, et al. Survival and outcome after hepatic artery thrombosis complicating pediatric liver transplantation. J Pediatr Surg. 2001;36:888–891
  97. Renz JF, Yersiz H, Reichert PR, Hisatake GM, Farmer DG, Emond JC, et al. Split-liver transplantation: a review. Am J Transplant. 2003;3:1323–1335
  98. Tzakis A, Todo S, Starzl TE. Orthotopic liver transplantation with preservation of the inferior vena cava. Ann Surg. 1989;210:649–652
  99. Quinones-Baldrich WJ, Memsic L, Ramming K, Hiatt J, Busuttil RW. Branch patch for arterialization of hepatic grafts. Surg Gynecol Obstet. 1986;162:488–490
  100. Lerut J, de Ville de Goyet J, Donataccio M, Reding R, Otte JB. Piggyback transplantation with side-to-side cavocavostomy is an ideal technique for right split liver allograft implantation. J Am Coll Surg. 1994;179:573–576
  101. Rela M, Muiesan P, Vilca-Melendez H, Dhawan A, Baker A, Mieli-Vergani G, et al. Auxiliary partial orthotopic liver transplantation for Crigler-Najjar syndrome type I. Ann Surg. 1999;229:565–569
  102. Kasahara M, Takada Y, Kozaki K, Uryuhara K, Ogura Y, Ogawa K, et al. Functional portal flow competition after auxiliary partial orthotopic living donor liver transplantation in noncirrhotic metabolic liver disease. J Pediatr Surg. 2004;39:1138–1141
  103. Kasahara M, Takada Y, Egawa H, Fujimoto Y, Ogura Y, Ogawa K, et al. Auxiliary partial orthotopic living donor liver transplantation: Kyoto University experience. Am J Transplant. 2005;5:558–565
  104. Broering DC, Walter J, Bassas AF. Overcoming the portal steal phenomenon in auxiliary partial orthotopic liver transplantation by modulation of the venous outflow of the native liver. Liver Transpl. 2005;11:1140–1143
  105. Mandell MS, Stoner TJ, Barnett R, Shaked A, Bellamy M, Biancofiore G, et al. A multicenter evaluation of safety of early extubation in liver transplant recipients. Liver Transpl. 2007;13:1557–1563
  106. Mandell MS, Lezotte D, Kam I, Zamudio S. Reduced use of intensive care after liver transplantation: influence of early extubation. Liver Transpl. 2002;8:676–681
  107. Clavien PA, Camargo CA, Croxford R, Langer B, Levy GA, Greig PD. Definition and classification of negative outcomes in solid organ transplantation (Application in liver transplantation). Ann Surg. 1994;220:109–120
  108. Broering DC, Wilms C, Bok P, Fischer L, Mueller L, Hillert C, et al. Evolution of donor morbidity in living related liver transplantation: a single-center analysis of 165 cases. Ann Surg. 2004;240:1013–1024discussions 1024-6
  109. Garcia-Criado A, Gilabert R, Bargallo X, Bru C. Radiology in liver transplantation. Semin Ultrasound CT MR. 2002;23:114–129
  110. Crossin JD, Muradali D, Wilson SR. US of liver transplants: normal and abnormal. Radiographics. 2003;23:1093–1114
  111. Quiroga J, Colina I, Demetris AJ, Starzl TE, Van Thiel DH. Cause and timing of first allograft failure in orthotopic liver transplantation: a study of 177 consecutive patients. Hepatology. 1991;14:1054–1062
  112. Tamsel S, Demirpolat G, Killi R, Aydin U, Kilic M, Zeytunlu M, et al. Vascular complications after liver transplantation: evaluation with Doppler US. Abdom Imaging. 2007;32:339–347
  113. Dodd GD, Memel DS, Zajko AB, Baron RL, Santaguida LA. Hepatic artery stenosis and thrombosis in transplant recipients: Doppler diagnosis with resistive index and systolic acceleration time. Radiology. 1994;192:657–661
  114. Caiado AH, Blasbalg R, Marcelino AS, da Cunha Pinho M, Chammas MC, da Costa Leite C, et al. Complications of liver transplantation: multimodality imaging approach. Radiographics. 2007;27:1401–1417
  115. Platt JF, Rubin JM, Ellis JH. Hepatic artery resistance changes in portal vein thrombosis. Radiology. 1995;196:95–98
  116. Marcos A, Olzinski AT, Ham JM, Fisher RA, Posner MP. The interrelationship between portal and arterial blood flow after adult to adult living donor liver transplantation. Transplantation. 2000;70:1697–1703
  117. Nghiem HV. Imaging of hepatic transplantation. Radiol Clin North Am. 1998;36:429–443
  118. Adani GL, Baccarani U, Risaliti A, Sponza M, Gasparini D, Bresadola F, et al. Percutaneous transhepatic portography for the treatment of early portal vein thrombosis after surgery. Cardiovasc Intervent Radiol. 2007;30:1222–1226
  119. Glockner JF, Forauer AR, Solomon H, Varma CR, Perman WH. Three-dimensional gadolinium-enhanced MR angiography of vascular complications after liver transplantation. AJR Am J Roentgenol. 2000;174:1447–1453
  120. Thuluvath PJ, Pfau PR, Kimmey MB, Ginsberg GG. Biliary complications after liver transplantation: the role of endoscopy. Endoscopy. 2005;37:857–863
  121. Jagannath S, Kalloo AN. Biliary complications after liver transplantation. Curr Treat Options Gastroenterol. 2002;5:101–112
  122. Rela M, Heaton ND. Split-liver transplantation. Br J Surg. 1998;85:881–883
  123. Moser MA, Wall WJ. Management of biliary problems after liver transplantation. Liver Transpl. 2001;7:S46–S52
  124. Verran DJ, Asfar SK, Ghent CN, Grant DR, Wall WJ. Biliary reconstruction without T tubes or stents in liver transplantation: report of 502 consecutive cases. Liver Transpl Surg. 1997;3:365–373
  125. Brown RS, Russo MW, Lai M, Shiffman ML, Richardson MC, Everhart JE, et al. A survey of liver transplantation from living adult donors in the United States. N Engl J Med. 2003;348:818–825
  126. Tung BY, Kimmey MB. Biliary complications of orthotopic liver transplantation. Dig Dis. 1999;17:133–144
  127. Rizk RS, McVicar JP, Emond MJ, Rohrmann CA, Kowdley KV, Perkins J, et al. Endoscopic management of biliary strictures in liver transplant recipients: effect on patient and graft survival. Gastrointest Endosc. 1998;47:128–135
  128. Rossi AF, Grosso C, Zanasi G, Gambitta P, Bini M, De Carlis L, et al. Long-term efficacy of endoscopic stenting in patients with stricture of the biliary anastomosis after orthotopic liver transplantation. Endoscopy. 1998;30:360–366
  129. Mahajani RV, Cotler SJ, Uzer MF. Efficacy of endoscopic management of anastomotic biliary strictures after hepatic transplantation. Endoscopy. 2000;32:943–949
  130. Perry I, Neuberger J. Immunosuppression: towards a logical approach in liver transplantation. Clin Exp Immunol. 2005;139:2–10
  131. Meier-Kriesche HU, Li S, Gruessner RW, Fung JJ, Bustami RT, Barr ML, et al. Immunosuppression: evolution in practice and trends, 1994-2004. Am J Transplant. 2006;6:1111–1131
  132. Wilkinson A, Pham PT. Kidney dysfunction in the recipients of liver transplants. Liver Transpl. 2005;11:S47–S51
  133. Detry O, de Roover A, Delwaide J, Meurisse M, Honoré P. The use of mycophenolate mofetil in liver transplant recipients. Expert Opin Pharmacother. 2003;4:1949–1957
  134. Neuhaus P, Klupp J, Langrehr JM. mTOR inhibitors: an overview. Liver Transpl. 2001;7:473–484
  135. Janus A, Robak T, Smolewski P. The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy. Cell Mol Biol Lett. 2005;10:479–498
  136. Smolewski P. Investigating mammalian target of rapamycin inhibitors for their anticancer properties. Expert Opin Investig Drugs. 2006;15:1201–1227
  137. Gomez-Camarero J, Salcedo M, Rincon D, Lo Iacono O, Ripoll C, Hernando A, et al. Use of everolimus as a rescue immunosuppressive therapy in liver transplant patients with neoplasms. Transplantation. 2007;84:786–791
  138. Everson GT. Everolimus and mTOR inhibitors in liver transplantation: opening the “box.”. Liver Transpl. 2006;12:1571–1573
  139. Mahe E, Morelon E, Lechaton S, Sang KH, Mansouri R, Ducasse MF, et al. Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy. Transplantation. 2005;79:476–482
  140. van Gelder T, ter Meulen CG, Hene R, Weimar W, Hoitsma A. Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil. Transplantation. 2003;75:788–791
  141. Kerkar N, Dugan C, Rumbo C, Morotti RA, Gondolesi G, Shneider BL, et al. Rapamycin successfully treats post-transplant autoimmune hepatitis. Am J Transplant. 2005;5:1085–1089
  142. Starzl TE, Marchioro TL, Vonkaulla KN, Hermann G, Brittain RS, Waddell WR. Homotransplantation of the liver in humans. Surg Gynecol Obstet. 1963;117:659–676
  143. Wiesner R, Rabkin J, Klintmalm G, McDiarmid S, Langnas A, Punch J, et al. A randomized double-blind comparative study of mycophenolate mofetil and azathioprine in combination with cyclosporine and corticosteroids in primary liver transplant recipients. Liver Transpl. 2001;7:442–450
  144. Lohse AW, Weiler-Norman C, Burdelski M. De novo autoimmune hepatitis after liver transplantation. Hepatol Res. 2007;37(suppl 3):S462
  145. Llado L, Xiol X, Figueras J, Ramos E, Memba R, Serrano T, et al. Immunosuppression without steroids in liver transplantation is safe and reduces infection and metabolic complications: results from a prospective multicenter randomized study. J Hepatol. 2006;44:710–716
  146. Ringe B, Braun F, Schutz E, Fuzesi L, Lorf T, Canelo R, et al. A novel management strategy of steroid-free immunosuppression after liver transplantation: efficacy and safety of tacrolimus and mycophenolate mofetil. Transplantation. 2001;71:508–515
  147. Tisone G, Orlando G, Cardillo A, Palmieri G, Manzia TM, Baiocchi L, et al. Complete weaning off immunosuppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence. J Hepatol. 2006;44:702–709
  148. Pomfret EA, Feng S, Hale DA, Magee JC, Mulligan M, Knechtle SJ. The Art and Science of Immunosuppression: the Fifth Annual American Society of Transplant Surgeon's State-of-the-Art Winter Symposium. Am J Transplant. 2006;6:275–280
  149. Eason JD, Cohen AJ, Nair S, Alcantera T, Loss GE. Tolerance: is it worth the risk?. Transplantation. 2005;79:1157–1159
  150. Fandrich F. Induction of tolerance in clinical organ transplantation. Nephrol Dial Transplant. 2006;21:1170–1173
  151. Langnas AN, Marujo W, Stratta RJ, Wood RP, Shaw BW. Vascular complications after orthotopic liver transplantation. Am J Surg. 1991;161:76–82discussion 82-3
  152. Millis JM, Seaman DS, Piper JB, Alonso EM, Kelly S, Hackworth CA, et al. Portal vein thrombosis and stenosis in pediatric liver transplantation. Transplantation. 1996;62:748–754
  153. Buell JF, Funaki B, Cronin DC, Yoshida A, Perlman MK, Lorenz J, et al. Long-term venous complications after full-size and segmental pediatric liver transplantation. Ann Surg. 2002;236:658–666
  154. Stenger AM, Broering DC, Gundlach M, Bloechle C, Ganschow R, Helmke K, et al. Extrahilar mesenterico-left portal shunt for portal vein thrombosis after liver transplantation. Transplant Proc. 2001;33:1739–1741
  155. de Ville de Goyet J, Clapuyt P, Otte JB. Extrahilar mesenterico-left portal shunt to relieve extrahepatic portal hypertension after partial liver transplant. Transplantation. 1992;53:231–232
  156. Kling K, Lau H, Colombani P. Biliary complications of living related pediatric liver transplant patients. Pediatr Transplant. 2004;8:178–184
  157. Vilca Melendez H, Vougas V, Muiesan P, Andreani P, Mieli-Vergani G, Rela M, et al. Bowel perforation after paediatric orthotopic liver transplantation. Transpl Int. 1998;11:301–304
  158. Penn I. Cancers complicating organ transplantation. N Engl J Med. 1990;323:1767–1769
  159. Muiesan P, Vergani D, Mieli-Vergani G. Liver transplantation in children. J Hepatol. 2007;46:340–348
  160. Jain A, Reyes J, Kashyap R, Dodson SF, Demetris AJ, Ruppert K, et al. Long-term survival after liver transplantation in 4,000 consecutive patients at a single center. Ann Surg. 2000;232:490–500
  161. Busuttil RW, Farmer DG, Yersiz H, Hiatt JR, McDiarmid SV, Goldstein LI, et al. Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience. Ann Surg. 2005;241:905–916discussion 916-8
  162. Burroughs AK, Sabin CA, Rolles K, Delvart V, Karam V, Buckels J, et al. 3-month and 12-month mortality after first liver transplant in adults in Europe: predictive models for outcome. Lancet. 2006;367:225–232
  163. van der Meulen JH, Lewsey JD, Dawwas MF, Copley LP. Adult orthotopic liver transplantation in the United Kingdom and Ireland between 1994 and 2005. Transplantation. 2007;84:572–579
  164. Adam R, McMaster P, O'Grady JG, Castaing D, Klempnauer JL, Jamieson N, et al. Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry. Liver Transpl. 2003;9:1231–1243
  165. Adam R, Lucidi V, Karam V. Liver transplantation in Europe: is there a room for improvement?. J Hepatol. 2005;42:33–40
  166. Roberts MS, Angus DC, Bryce CL, Valenta Z, Weissfeld L. Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl. 2004;10:886–897
  167. Pomfret EA, Fryer JP, Sima CS, Lake JR, Merion RM. Liver and intestine transplantation in the United States, 1996-2005. Am J Transplant. 2007;7:1376–1389
  168. Cardillo M, De Fazio N, Pedotti P, De Feo T, Fassati LR, Mazzaferro V, et al. Split and whole liver transplantation outcomes: a comparative cohort study. Liver Transpl. 2006;12:402–410
  169. Spada M, Cescon M, Aluffi A, Zambelli M, Guizzetti M, Lucianetti A, et al. Use of extended right grafts from in situ split livers in adult liver transplantation: a comparison with whole-liver transplants. Transplant Proc. 2005;37:1164–1166
  170. Porta E, Cardillo M, Pizzi C, Poli F, Scalamogna M, Sirchia G. Split liver is an effective tool to transplant paediatric patients. Transpl Int. 2000;13(suppl 1):S144–S146
  171. Margarit C, Asensio M, Iglesias J, Bilbao I, Ortega J, Lazaro JL, et al. Outcome of 28 split liver grafts. Transplant Proc. 2003;35:1812–1814
  172. Moreno A, Meneu JC, Moreno E, Garcia I, Loinaz C, Jimenez C, et al. Results in split liver transplantation. Transplant Proc. 2003;35:1810–1811
  173. Washburn K, Halff G, Mieles L, Goldstein R, Goss JA. Split-liver transplantation: results of statewide usage of the right trisegmental graft. Am J Transplant. 2005;5:1652–1659
  174. Cintorino D, Spada M, Gruttadauria S, Riva S, Luca A, Volpes R, et al. In situ split liver transplantation for adult and pediatric recipients: an answer to organ shortage. Transplant Proc. 2006;38:1096–1098
  175. Baccarani U, Adani GL, Risaliti A, Sainz-Barriga M, Lorenzin D, Chiarandini P, et al. Long-term results of in situ split-liver transplantation. Transplant Proc. 2005;37:2592–2594
  176. Sampietro R, Goffette P, Danse E, De Reyck C, Roggen F, Ciccarelli O, et al. Extension of the adult hepatic allograft pool using split liver transplantation. Acta Gastroenterol Belg. 2005;68:369–375
  177. Corno V, Colledan M, Dezza MC, Guizzetti M, Lucianetti A, Maldini G, et al. Extended right split liver graft for primary transplantation in children and adults. Transpl Int. 2006;19:492–499
  178. Rela M, Vougas V, Muiesan P, Vilca-Melendez H, Smyrniotis V, Gibbs P, et al. Split liver transplantation: King's College Hospital experience. Ann Surg. 1998;227:282–288
  179. Nashan B, Luck R, Becker T, Grannas G, Strassburg C, Schneider A, et al. Expansion of the donor pool in liver transplantation: the Hannover experience 1996-2002. Clin Transpl. 2002;221–228
  180. Sauer IM, Pascher A, Steinmuller T, Settmacher U, Muller AR, Bechstein WO, et al. Split liver and living donation liver transplantation: the Berlin experience. Transplant Proc. 2001;33:1459–1460
  181. Maggi U, Rossi G, Reggiani P, et al. Graft loss and retransplantation rate after split in situ liver transplantation (Joint Meeting of the International Liver Transplantation Society, European Liver transplantation Association and Liver Intensive Care Group of Europe. Berlin, Germany, July 11-13, 2001). Liver Transpl. 2001;7
  182. Kilic M, Seu P, Goss JA. Maintenance of the celiac trunk with the left-sided liver allograft for in situ split-liver transplantation. Transplantation. 2002;73:1252–1257
  183. Goss JA, Yersiz H, Shackleton CR, Seu P, Smith CV, Markowitz JS, et al. In situ splitting of the cadaveric liver for transplantation. Transplantation. 1997;64:871–877
  184. Reyes J, Gerber D, Mazariegos GV, Casavilla A, Sindhi R, Bueno J, et al. Split-liver transplantation: a comparison of ex vivo and in situ techniques. J Pediatr Surg. 2000;35:283–289discussion 289-90
  185. Andorno E, Genzone A, Morelli N, Mondello R, Colledan M, Gridelli B, et al. One liver for two adults: in situ split liver transplantation for two adult recipients. Transplant Proc. 2001;33:1420–1422
  186. Giacomoni A, De Carlis L, Lauterio A, Slim AO, Aseni P, Sammartino C, et al. Right hemiliver transplant: results from living and cadaveric donors. Transplant Proc. 2005;37:1167–1169
  187. Adham M, Dumortier J, Abdelaal A, Sagnard P, Boucaud C, Boillot O. Does middle hepatic vein omission in a right split graft affect the outcome of liver transplantation? (A comparative study of right split livers with and without the middle hepatic vein). Liver Transpl. 2007;13:829–837
  188. Colledan M, Andorno E, Segalin A, Lucianetti A, Spada M, Corno V, et al. Alternative split liver technique: the equal size split. Transplant Proc. 2001;33:1335–1336
  189. Goss JA, Shackleton CR, McDiarmid SV, Maggard M, Swenson K, Seu P, et al. Long-term results of pediatric liver transplantation: an analysis of 569 transplants. Ann Surg. 1998;228:411–420
  190. Mirza DF, Achilleos O, Pirenne J, Buckels JA, McMaster P, Mayer AD. Encouraging results of split-liver transplantation. Br J Surg. 1998;85:494–497
  191. Chardot C, Branchereau S, de Dreuzy O, Dubuisson C, Le Pommelet C, Waguet J, et al. Paediatric liver transplantation with a split graft: experience at Bicetre. Eur J Pediatr Surg. 1999;9:146–152
  192. Broering DC, Mueller L, Ganschow R, Kim JS, Achilles EG, Schafer H, et al. Is there still a need for living-related liver transplantation in children?. Ann Surg. 2001;234:713–721discussion 721-2
  193. Farmer DG, Yersiz H, Ghobrial RM, McDiarmid SV, Gornbein J, Le H, et al. Early graft function after pediatric liver transplantation: comparison between in situ split liver grafts and living-related liver grafts. Transplantation. 2001;72:1795–1802
  194. Langham MR, Tzakis AG, Gonzalez-Peralta R, Thompson JF, Rosen CB, Nery JR, et al. Graft survival in pediatric liver transplantation. J Pediatr Surg. 2001;36:1205–1209
  195. Deshpande RR, Bowles MJ, Vilca-Melendez H, Srinivasan P, Girlanda R, Dhawan A, et al. Results of split liver transplantation in children. Ann Surg. 2002;236:248–253
  196. Gridelli B, Spada M, Petz W, Bertani A, Lucianetti A, Colledan M, et al. Split-liver transplantation eliminates the need for living-donor liver transplantation in children with end-stage cholestatic liver disease. Transplantation. 2003;75:1197–1203
  197. Lee TC, Barshes NR, Washburn WK, Halff GA, Carter BA, Karpen SJ, et al. Split-liver transplantation using the left lateral segment: a collaborative sharing experience between two distant centers. Am J Transplant. 2005;5:1646–1651
  198. Kim JS, Groteluschen R, Mueller T, Ganschow R, Bicak T, Wilms C, et al. Pediatric transplantation: the Hamburg experience. Transplantation. 2005;79:1206–1209
  199. Corno V, Torri E, Bertani A, Guizzetti M, Lucianetti A, Maldini G, et al. Early portal vein thrombosis after pediatric split liver transplantation with left lateral segment graft. Transplant Proc. 2005;37:1141–1142
  200. Abt PL, Rapaport-Kelz R, Desai NM, Frank A, Sonnad S, Rand E, et al. Survival among pediatric liver transplant recipients: impact of segmental grafts. Liver Transpl. 2004;10:1287–1293
  201. Sindhi R, Rosendale J, Mundy D, Taranto S, Baliga P, Reuben A, et al. Impact of segmental grafts on pediatric liver transplantation—a review of the United Network for Organ Sharing Scientific Registry data (1990-1996). J Pediatr Surg. 1999;34:107–110discussion 110-1
  202. Diamond IR, Fecteau A, Millis JM, Losanoff JE, Ng V, Anand R, et al. Impact of graft type on outcome in pediatric liver transplantation: a report from studies of pediatric liver transplantation (SPLIT). Ann Surg. 2007;246:301–310
  203. Burdelski MM, Rogiers X. What lessons have we learned in pediatric liver transplantation?. J Hepatol. 2005;42:28–33
  204. Wallot MA, Mathot M, Janssen M, Holter T, Paul K, Buts JP, et al. Long-term survival and late graft loss in pediatric liver transplant recipients—a 15-year single-center experience. Liver Transpl. 2002;8:615–622
  205. Gridelli B, Remuzzi G. Strategies for making more organs available for transplantation. N Engl J Med. 2000;343:404–410
  206. de Ville de Goyet J, Hausleithner V, Reding R, Lerut J, Janssen M, Otte JB. Impact of innovative techniques on the waiting list and results in pediatric liver transplantation. Transplantation. 1993;56:1130–1136
  207. Troisi R, Noens L, Montalti R, Ricciardi S, Philippe J, Praet M, et al. ABO-mismatch adult living donor liver transplantation using antigen-specific immunoadsorption and quadruple immunosuppression without splenectomy. Liver Transpl. 2006;12:1412–1417
  208. Kozaki K, Egawa H, Kasahara M, Oike F, Yoshizawa A, Fukatsu A, et al. Therapeutic strategy and the role of apheresis therapy for ABO incompatible living donor liver transplantation. Ther Apher Dial. 2005;9:285–291
  209. Egawa H, Oike F, Buhler L, Shapiro AM, Minamiguchi S, Haga H, et al. Impact of recipient age on outcome of ABO-incompatible living-donor liver transplantation. Transplantation. 2004;77:403–411
  210. Egawa H, Teramukai S, Haga H, Tanabe M, Fukushima M, Shimazu M. Present status of ABO-incompatible living donor liver transplantation in Japan. Hepatology. 2008;47:11–13
  211. Kucher N, Tapson VF, Goldhaber SZ. Risk factors associated with symptomatic pulmonary embolism in a large cohort of deep vein thrombosis patients. Thromb Haemost. 2005;93:494–498
  212. Durand F, Ettorre GM, Douard R, Denninger MH, Kianmanesh A, Sommacale D, et al. Donor safety in living related liver transplantation: underestimation of the risks for deep vein thrombosis and pulmonary embolism. Liver Transpl. 2002;8:118–120[see comment]
  213. Broering DC, Sterneck M, Rogiers X. Living donor liver transplantation. J Hepatol. 2003;38(suppl 1):S119–S135
  214. Middleton PF, Duffield M, Lynch SV, Padbury RT, House T, Stanton P, et al. Living donor liver transplantation—adult donor outcomes: a systematic review. Liver Transplantation. 2006;12:24–30
  215. Fan ST, Lo CM, Liu CL, Yong BH, Chan JK, Ng IO. Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg. 2000;135:336–340
  216. Lo CM, Fan ST, Liu CL, Chan JK, Lam BK, Lau GK, et al. Minimum graft size for successful living donor liver transplantation. Transplantation. 1999;68:1112–1116
  217. Enne M, Pacheco-Moreira L, Balbi E, Cerqueira A, Santalucia G, Martinho JM. Liver transplantation with monosegments (Technical aspects and outcome: a meta-analysis). Liver Transpl. 2005;11:564–569
  218. Kasahara M, Kaihara S, Oike F, Ito T, Fujimoto Y, Ogura Y, et al. Living-donor liver transplantation with monosegments. Transplantation. 2003;76:694–696[see comment]
  219. Lee SG, Hwang S, Park KM, Kim KH, Ahn CS, Lee YJ, et al. Seventeen adult-to-adult living donor liver transplantations using dual grafts. Transplant Proc. 2001;33:3461–3463
  220. Broering DC, Walter J, Rogiers X. The first two cases of living donor liver transplantation using dual grafts in Europe. Liver Transpl. 2007;13:149–153
  221. Marcos A, Ham JM, Fisher RA, Olzinski AT, Shiffman ML, Sanyal AJ, et al. Emergency adult to adult living donor liver transplantation for fulminant hepatic failure. Transplantation. 2000;69:2202–2205[see comment]
  222. Testa G, Malago M, Nadalin S, Hertl M, Lang H, Frilling A, et al. Right-liver living donor transplantation for decompensated end-stage liver disease. Liver Transpl. 2002;8:340–346[see comment]
  223. Kam I. Adult-adult right hepatic lobe living donor liver transplantation for status 2a patients: too little, too late [comment]. Liver Transpl. 2002;8:347–349
  224. Todo S, Furukawa H. Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan. Ann Surg. 2004;240:451–459discussion 459-61
  225. Soubrane O, Cherqui D, Scatton O, Stenard F, Bernard D, Branchereau S, et al. Laparoscopic left lateral sectionectomy in living donors: safety and reproducibility of the technique in a single center. Ann Surg. 2006;244:815–820
  226. Fan ST, Lo CM, Liu CL, Wang WX, Wong J. Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation. Ann Surg. 2003;238:137–148
  227. Shah SA, Grant DR, Greig PD, McGilvray ID, Adcock LD, Girgrah N, et al. Analysis and outcomes of right lobe hepatectomy in 101 consecutive living donors. Am J Transplant. 2005;5:2764–2769
  228. Scatton O, Belghiti J, Dondero F, Goere D, Sommacale D, Plasse M, et al. Harvesting the middle hepatic vein with a right hepatectomy does not increase the risk for the donor. Liver Transpl. 2004;10:71–76
  229. Salvalaggio PR, Baker TB, Koffron AJ, Fryer JP, Clark L, Superina RA, et al. Comparative analysis of live liver donation risk using a comprehensive grading system for severity. Transplantation. 2004;77:1765–1767
  230. Nadalin S, Malago M, Radtke A, Erim Y, Saner F, Valentin-Gamazo C, et al. Current trends in live liver donation. Transpl Int. 2007;20:312–330
  231. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213
  232. Nanashima A, Yamaguchi H, Shibasaki S, Ide N, Morino S, Sumida Y, et al. Comparative analysis of postoperative morbidity according to type and extent of hepatectomy. Hepatogastroenterology. 2005;52:844–848
  233. Umeshita K, Fujiwara K, Kiyosawa K, Makuuchi M, Satomi S, Sugimachi K, et al. Operative morbidity of living liver donors in Japan. Lancet. 2003;362:687–690
  234. Otte JB. Donor complications and outcomes in live-liver transplantation. Transplantation. 2003;75:1625–1626
  235. Barr ML, Belghiti J, Villamil FG, Pomfret EA, Sutherland DS, Gruessner RW, et al. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation. 2006;81:1373–1385
  236. Renz JF, Kin CJ, Saggi BH, Emond JC. Outcomes of living donor liver transplantation. In:  Busuttil RW editors. Transplantation of the Liver. Philadelphia: Elsevier; 2005;p. 713–724
  237. Pratschke J, Neuhaus P, Tullius SG. What can be learned from brain-death models?. Transpl Int. 2005;18:15–21
  238. Thuluvath PJ, Yoo HY. Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation. Liver Transpl. 2004;10:1263–1268
  239. Maluf DG, Stravitz RT, Cotterell AH, Posner MP, Nakatsuka M, Sterling RK, et al. Adult living donor versus deceased donor liver transplantation: a 6-year single center experience. Am J Transplant. 2005;5:149–156
  240. Liu CL, Fan ST, Lo CM, Wei WI, Chan SC, Yong BH, et al. Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center. Ann Surg. 2006;243:404–410
  241. Roberts JP, Hulbert-Shearon TE, Merion RM, Wolfe RA, Port FK. Influence of graft type on outcomes after pediatric liver transplantation. Am J Transplant. 2004;4:373–377
  242. Inomata Y, Uemoto S, Asonuma K, Egawa H. Right lobe graft in living donor liver transplantation. Transplantation. 2000;69:258–264
  243. Marcos A, Ham JM, Fisher RA, Olzinski AT, Posner MP. Single-center analysis of the first 40 adult-to-adult living donor liver transplants using the right lobe. Liver Transpl. 2000;6:296–301
  244. Grewal HP, Shokouh-Amiri MH, Vera S, Stratta R, Bagous W, Gaber AO. Surgical technique for right lobe adult living donor liver transplantation without venovenous bypass or portocaval shunting and with duct-to-duct biliary reconstruction. Ann Surg. 2001;233:502–508
  245. Lee SG, Park KM, Lee YJ, Hwang S, Choi DR, Ahn CS, et al. 157 adult-to-adult living donor liver transplantation. Transplant Proc. 2001;33:1323–1325
  246. Bak T, Wachs M, Trotter J, Everson G, Trouillot T, Kugelmas M, et al. Adult-to-adult living donor liver transplantation using right-lobe grafts: results and lessons learned from a single-center experience. Liver Transpl. 2001;7:680–686
  247. Miller CM, Gondolesi GE, Florman S, Matsumoto C, Munoz L, Yoshizumi T, et al. One hundred nine living donor liver transplants in adults and children: a single-center experience. Ann Surg. 2001;234:301–311discussion 311-2
  248. Hashikura Y, Kawasaki S, Terada M, Ikegami T, Nakazawa Y, Urata K, et al. Long-term results of living-related donor liver graft transplantation: a single-center analysis of 110 transplants. Transplantation. 2001;72:95–99
  249. Hirata M, Sugawara Y, Makuuchi M. Living-donor liver transplantation at Tokyo University. Clin Transpl. 2002;215–219
  250. Sugawara Y, Makuuchi M, Kaneko J, Ohkubo T, Matsui Y, Imamura H, et al. Living-donor liver transplantation in adults: Tokyo University experience. J Hepatobiliary Pancreat Surg. 2003;10:1–4
  251. Malago M, Testa G, Frilling A, Nadalin S, Valentin-Gamazo C, Paul A, et al. Right living donor liver transplantation: an option for adult patients: single institution experience with 74 patients. Ann Surg. 2003;238:853–862discussion 862-3
  252. Lo CM, Fan ST, Liu CL, Yong BH, Wong Y, Lau GK, et al. Lessons learned from one hundred right lobe living donor liver transplants. Ann Surg. 2004;240:151–158
  253. Gondolesi GE, Varotti G, Florman SS, Munoz L, Fishbein TM, Emre SH, et al. Biliary complications in 96 consecutive right lobe living donor transplant recipients. Transplantation. 2004;77:1842–1848
  254. Austin MT, Feurer ID, Chari RS, Gorden DL, Wright JK, Pinson CW. Survival after pediatric liver transplantation: why does living donation offer an advantage?. Arch Surg. 2005;140:465–470discussion 470-1
  255. Olthoff KM, Merion RM, Ghobrial RM, Abecassis MM, Fair JH, Fisher RA, et al. Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium. Ann Surg. 2005;242:314–323discussion 323-5
  256. Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Harada N, Ijichi H, et al. Feasibility of left lobe living donor liver transplantation between adults: an 8-year, single-center experience of 107 cases. Am J Transplant. 2006;6:1004–1011
  257. Bourdeaux C, Darwish A, Jamart J, Tri TT, Janssen M, Lerut J, et al. Living-related versus deceased donor pediatric liver transplantation: a multivariate analysis of technical and immunological complications in 235 recipients. Am J Transplant. 2007;7:440–447
  258. Emiroglu R, Sevmis S, Moray G, Savas N, Haberal M. Living-donor liver transplantation: results of a single center. Transplant Proc. 2007;39:1149–1152
  259. Heffron TG. Living related liver transplantation. Semin Liver Dis. 1995;15:165–172
  260. Hayashi M, Cao S, Concepcion W, Monge H, Ojogho O, So S, et al. Current status of living-related liver transplantation. Pediatr Transplant. 1998;2:16–25
  261. Forsberg A, Nilsson M, Krantz M, Olausson M. The essence of living parental liver donation-donors' lived experiences of donation to their children. Pediatr Transplant. 2004;8:372–380
  262. Ross LF, Glannon W, Josephson MA, Thistlethwaite JR. Should all living donors be treated equally?. Transplantation. 2002;74:418–421discussion 421-2
  263. Barshes NR, Lee TC, Udell IW, O'Mahoney CA, Carter BA, Karpen SJ, et al. Adult liver transplant candidate attitudes toward graft sharing are not obstacles to split liver transplantation. Am J Transplant. 2005;5:2047–2051
  264. Vulchev A, Roberts JP, Stock PG. Ethical issues in split versus whole liver transplantation. Am J Transplant. 2004;4:1737–1740
  265. O'Grady JG. Clinical economics review: liver transplantation. Aliment Pharmacol Ther. 1997;11:445–451
  266. Wong LL, McFall P, Wong LM. The cost of dying of end-stage liver disease. Arch Intern Med. 1997;157:1429–1432
  267. Englesbe MJ, Dimick J, Mathur A, Ads Y, Welling TH, Pelletier SJ, et al. Who pays for biliary complications following liver transplant? (A business case for quality improvement). Am J Transplant. 2006;6:2978–2982
  268. Devlin J, Doherty D, Thomson L, Wong T, Donaldson P, Portmann B, et al. Defining the outcome of immunosuppression withdrawal after liver transplantation. Hepatology. 1998;27:926–933
  269. Kanmaz T, Fechner JJ, Torrealba J, Kim HT, Dong Y, Oberley TD, et al. Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model. Transplantation. 2004;77:914–920
  270. Vincenti F, Larsen C, Durrbach A, Wekerle T, Nashan B, Blancho G, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med. 2005;353:770–781
  271. Calne R, Friend P, Moffatt S, Bradley A, Hale G, Firth J, et al. Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet. 1998;351:1701–1702
  272. Kirk AD, Mannon RB, Kleiner DE, Swanson JS, Kampen RL, Cendales LK, et al. Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin. Transplantation. 2005;80:1051–1059
  273. Marcos A, Eghtesad B, Fung JJ, Fontes P, Patel K, Devera M, et al. Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virus. Transplantation. 2004;78:966–971
  274. Fandrich F, Schulze M, Zehle G, Lange H, Ungefroren H. Stem cell-mediated tolerance inducing strategies in organ transplantation. Kidney Int. 2004;65:1548–1550
  275. Donckier V, Troisi R, Le Moine A, Toungouz M, Ricciardi S, Colle I, et al. Early immunosuppression withdrawal after living donor liver transplantation and donor stem cell infusion. Liver Transpl. 2006;12:1523–1528
  276. Grompe M. Principles of therapeutic liver repopulation. J Inherit Metab Dis. 2006;29:421–425
  277. Overturf K, Al-Dhalimy M, Tanguay R, Brantly M, Ou CN, Finegold M, et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet. 1996;12:266–273
  278. Laconi E, Oren R, Mukhopadhyay DK, Hurston E, Laconi S, Pani P, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol. 1998;153:319–329
  279. Guha C, Parashar B, Deb NJ, Sharma A, Gorla GR, Alfieri A, et al. Liver irradiation: a potential preparative regimen for hepatocyte transplantation. Int J Radiat Oncol Biol Phys. 2001;49:451–457
  280. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents. Gastroenterology. 1996;111:1092–1102
  281. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med. 1998;338:1422–1426
  282. Horslen SP, McCowan TC, Goertzen TC, Warkentin PI, Cai HB, Strom SC, et al. Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics. 2003;111:1262–1267
  283. Sokal EM, Smets F, Bourgois A, Van Maldergem L, Buts JP, Reding R, et al. Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up. Transplantation. 2003;76:735–738
  284. Muraca M, Gerunda G, Neri D, Vilei MT, Granato A, Feltracco P, et al. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet. 2002;359:317–318
  285. Gouon-Evans V, Boussemart L, Gadue P, Nierhoff D, Koehler CI, Kubo A, et al. BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol. 2006;24:1402–1411
  286. Heo J, Factor VM, Uren T, Takahama Y, Lee JS, Major M, et al. Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver. Hepatology. 2006;44:1478–1486
  287. Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature. 2003;422:901–904
  288. Newsome PN, Johannessen I, Boyle S, Dalakas E, McAulay KA, Samuel K, et al. Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology. 2003;124:1891–1900
  289. Ruhnke M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, et al. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology. 2005;128:1774–1786
  290. Ruhnke M, Nussler AK, Ungefroren H, Hengstler JG, Kremer B, Hoeckh W, et al. Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy. Transplantation. 2005;79:1097–1103
  291. Gordon MY, Levicar N, Pai M, Bachellier P, Dimarakis I, Al-Allaf F, et al. Characterization and clinical application of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. Stem Cells. 2006;24:1822–1830
  292. Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells. 2006;24:2292–2298
  293. Furst G, Schulte am Esch J, Poll LW, Hosch SB, Fritz LB, Klein M, et al. Portal vein embolization and autologous CD133+ bone marrow stem cells for liver regeneration: initial experience. Radiology. 2007;243:171–179
  294. Masetti M, Siniscalchi A, De Pietri L, Braglia V, Benedetto F, Di Cautero N, et al. Living donor liver transplantation with left liver graft. Am J Transplant. 2004;4:1713–1716
  295. Shimada M, Ijichi H, Yonemura Y, Harada N, Shiotani S, Ninomiya M, et al. The impact of splenectomy or splenic artery ligation on the outcome of a living donor adult liver transplantation using a left lobe graft. Hepatogastroenterology. 2004;51:625–629
  296. Maggi U, Rossi G, Reggiani P, Caccamo L, Gatti S, Paone G, et al. Liver retransplantations with split in situ grafts in pediatric recipients. Transplant Proc. 2001;33:3614

PII: S0011-3840(08)00081-6

doi: 10.1067/j.cpsurg.2008.05.002

Current Problems in Surgery
Volume 45, Issue 9 , Pages 587-661 , September 2008