Current Problems in Surgery RSS feed: Current Issue. Current Problems in Surgery keeps readers up-to-date on the latest surgical advances. Each month, this publication examines a single clinical problem or condition commonly seen by general surgeons. Issues also focus on topics in surgical research and emerging ideas in surgical subspecialties. Current Problems in Surgery is ideal for information too urgent to await book publication, yet too important to be summarized in a brief journal article. 2010 Topics, Volume 47 January Hepatocellular Carcinoma: Current Management Charles H. Cha, M. Wasif Saif, Brett H. Yamane, and Sharon M. Weber February Benchmarking Best Practices in Weight Loss Surgery LTC Robert B. Lim, George L. Blackburn, and Daniel B. Jones March Care of the Pediatric Cardiac Surgery Patient?Part 1 Avihu Z. Gazit, Charles B. Huddleston, Paul A. Checchia, James Fehr, and A. Thomas Pezzella April Care of the Pediatric Cardiac Surgery Patient?Part 2 Avihu Z. Gazit, Charles B. Huddleston, Paul A. Checchia, James Fehr, and A. Thomas Pezzella May Cutaneous Manifestations of Internal Malignancy B enjamin D. Ehst, Karen Minzer-Conzetti, Amy Swerdlin, and Theresa Schroeder Devere June Pancreatic Cystic Neoplasm Kevin K. Roggin, Jennifer Chennat, Aytekin Oto, Amy Noffsinger, Alexandra Briggs, Jeffrey B. Matthewshttp://www.currprobsurg.com/?rss=yesElsevier Inc.en © 2010 Published by Elsevier Inc. All rights reserved. Current Problems in Surgery0011-38404710October 2010 © 2010 Published by Elsevier Inc. All rights reserved. healthpermissions@elsevier.comhttp://www.currprobsurg.com/article/PIIS0011384010001504/abstract?rss=yesTable of Contents10.1067/S0011-3840(10)00150-4Current Problems in Surgery 47, 10 (2010)2010-10-01Current Problems in Surgery2010-10-014710S0011-3840(10)X0009-0740741http://www.currprobsurg.com/article/PIIS0011384010001358/abstract?rss=yesThe complete sequencing of the human genome in conjunction with increasingly sophisticated molecular biological techniques have dramatically increased our understanding of the genetic events leading to carcinogenesis. Today, new cancer-related genetic changes seem to be described almost daily and the full potential of genetic profiling of individuals for cancer risk has yet to be realized. Although such profiling will represent an enormous advance, the full therapeutic implications of this technology are only beginning to be understood. For the surgeon, these advances have the potential to not only alter the role of surgery in traditional treatment paradigms but also offer the possibility of prophylactic intervention in at-risk individuals before cancer development. Although this latter approach may eventually be used in individuals at risk for the development of sporadic tumors, today it is generally reserved for prevention in patients with a hereditary disposition to specific cancers. In this issue of Current Problems in Surgery, Dr. Ismail Jatoi from the University of Texas Health Science Center in San Antonio and colleagues from around the country have written a masterful overview on this topic entitled, “The Role of Surgery in Cancer Prevention.” Beginning with a broad overview of cancer genetics, they then discuss the use of surgery for cancer prevention in individuals with hereditary cancers of the breast, stomach, thyroid, and colon. In each case, they review the predisposing genetic changes and the role of genetic testing and counseling. Benefits and risks of such an approach are clearly outlined and surgical options and outcomes are discussed in considerable detail. This thorough review should become an essential resource for all physicians caring for these patients and their families. It establishes a foundation for considering surgical options in other settings as genetic cancer risk profiling becomes a reality.ForewordStanley W. Ashley10.1067/j.cpsurg.2010.06.003Current Problems in Surgery 47, 10 (2010)2010-10-01Current Problems in Surgery2010-10-014710S0011-3840(10)X0009-0742742http://www.currprobsurg.com/article/PIIS0011384010001334/abstract?rss=yesMost (but not all) individuals who are candidates for prophylactic surgery have a hereditary predisposition for cancer, and the wider use of genetic testing has identified greater numbers of these individuals. For individuals with a hereditary predisposition for cancer, it is important to emphasize that there are no randomized prospective studies that have addressed the impact of prophylactic surgery on outcomes. Thus, the efficacy of prophylactic surgery is not fully understood, and patients should be fully informed of its potential risks and benefits.In BriefIsmail Jatoi, John R. Benson, Siong-Seng Liau, Yijun Chen, Robin M. Cisco, Jeffrey A. Norton, Jeffrey F. Moley, Katherine W. Khalifeh, Michael A. Choti10.1067/j.cpsurg.2010.06.001Current Problems in Surgery 47, 10 (2010)2010-10-01Current Problems in Surgery2010-10-014710S0011-3840(10)X0009-0743747http://www.currprobsurg.com/article/PIIS0011384010001346/abstract?rss=yesFor individuals at increased risk for certain cancers, surgery is a potential means of reducing that risk. Many of these individuals have a hereditary predisposition for specific cancers, and since the advent of genetic testing, surgery has been increasingly used as a cancer prevention tool. In this monograph, we discuss the management of individuals at increased risk for breast, gastric, thyroid, and colorectal cancers. We begin this monograph with a broad overview of cancer genetics and then discuss the role of surgery in cancer prevention among individuals with hereditary cancer syndromes. It should be emphasized that the overall impact of surgery in cancer prevention has not been fully elucidated, and surgeons should inform patients not only about the potential for benefit, but also the potential for harm.The Role of Surgery in Cancer PreventionIsmail Jatoi, John R. Benson, Siong-Seng Liau, Yijun Chen, Robin M. Cisco, Jeffrey A. Norton, Jeffrey F. Moley, Katherine W. Khalifeh, Michael A. Choti10.1067/j.cpsurg.2010.06.002Current Problems in Surgery 47, 10 (2010)2010-10-01Current Problems in Surgery2010-10-014710S0011-3840(10)X0009-0750830